Atomically unveiling the structure-activity relationship of biomacromolecule-metal-organic frameworks symbiotic crystal

Linjing Tong, Siming Huang, Yujian Shen, Suya Liu, Xiaomin Ma, Fang Zhu, Guosheng Chen () and Gangfeng Ouyang
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Linjing Tong: Sun Yat-sen University
Siming Huang: Guangzhou Medical University
Yujian Shen: Sun Yat-sen University
Suya Liu: Shanghai Nanoport, Thermo Fisher Scientific
Xiaomin Ma: Southern University of Science and Technology
Fang Zhu: Sun Yat-sen University
Guosheng Chen: Sun Yat-sen University
Gangfeng Ouyang: Sun Yat-sen University

Nature Communications, 2022, vol. 13, issue 1, 1-9

Abstract: Abstract Crystallization of biomacromolecules-metal-organic frameworks (BMOFs) allows for orderly assemble of symbiotic hybrids with desirable biological and chemical functions in one voxel. The structure-activity relationship of this symbiotic crystal, however, is still blurred. Here, we directly identify the atomic-level structure of BMOFs, using the integrated differential phase contrast-scanning transmission electron microscopy, cryo-electron microscopy and x-ray absorption fine structure techniques. We discover an obvious difference in the nanoarchitecture of BMOFs under different crystallization pathways that was previously not seen. In addition, we find the nanoarchitecture significantly affects the bioactivity of the BMOFs. This work gives an important insight into the structure-activity relationship of BMOFs synthesized in different scenarios, and may act as a guide to engineer next-generation materials with excellent biological and chemical functions.

Date: 2022
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DOI: 10.1038/s41467-022-28615-y

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