Nuclear genome of Bulinus truncatus, an intermediate host of the carcinogenic human blood fluke Schistosoma haematobium

Neil D. Young (), Andreas J. Stroehlein, Tao Wang, Pasi K. Korhonen, Margaret Mentink-Kane, J. Russell Stothard, David Rollinson and Robin B. Gasser ()
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Neil D. Young: The University of Melbourne
Andreas J. Stroehlein: The University of Melbourne
Tao Wang: The University of Melbourne
Pasi K. Korhonen: The University of Melbourne
Margaret Mentink-Kane: NIH-NIAID Schistosomiasis Resource Center, Biomedical Research Institute (BRI)
J. Russell Stothard: Liverpool School of Tropical Medicine
David Rollinson: Natural History Museum
Robin B. Gasser: The University of Melbourne

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract Some snails act as intermediate hosts (vectors) for parasitic flatworms (flukes) that cause neglected tropical diseases, such as schistosomiases. Schistosoma haematobium is a blood fluke that causes urogenital schistosomiasis and induces bladder cancer and increased risk of HIV infection. Understanding the molecular biology of the snail and its relationship with the parasite could guide development of an intervention approach that interrupts transmission. Here, we define the genome for a key intermediate host of S. haematobium—called Bulinus truncatus—and explore protein groups inferred to play an integral role in the snail’s biology and its relationship with the schistosome parasite. Bu. truncatus shared many orthologous protein groups with Biomphalaria glabrata—the key snail vector for S. mansoni which causes hepatointestinal schistosomiasis in people. Conspicuous were expansions in signalling and membrane trafficking proteins, peptidases and their inhibitors as well as gene families linked to immune response regulation, such as a large repertoire of lectin-like molecules. This work provides a sound basis for further studies of snail-parasite interactions in the search for targets to block schistosomiasis transmission.

Date: 2022
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DOI: 10.1038/s41467-022-28634-9

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