Prognostic tools and candidate drugs based on plasma proteomics of patients with severe COVID-19 complications

Maryam A. Y. Al-Nesf, Houari B. Abdesselem, Ilham Bensmail, Shahd Ibrahim, Walaa A. H. Saeed, Sara S. I. Mohammed, Almurtada Razok, Hashim Alhussain, Reham M. A. Aly, Muna Al Maslamani, Khalid Ouararhni, Mohamad Y. Khatib, Ali Ait Hssain, Ali S. Omrani, Saad Al-Kaabi, Abdullatif Al Khal, Asmaa A. Al-Thani, Waseem Samsam, Abdulaziz Farooq, Jassim Al-Suwaidi, Mohammed Al-Maadheed, Heba H. Al-Siddiqi, Alexandra E. Butler, Julie V. Decock, Vidya Mohamed-Ali and Fares Al-Ejeh ()
Additional contact information
Maryam A. Y. Al-Nesf: Hamad General Hospital, Hamad Medical Corporation
Houari B. Abdesselem: Hamad Bin Khalifa University, Qatar Foundation
Ilham Bensmail: Hamad Bin Khalifa University, Qatar Foundation
Shahd Ibrahim: Hamad General Hospital, Hamad Medical Corporation
Walaa A. H. Saeed: Hamad General Hospital, Hamad Medical Corporation
Sara S. I. Mohammed: Hamad General Hospital, Hamad Medical Corporation
Almurtada Razok: Hamad General Hospital, Hamad Medical Corporation
Hashim Alhussain: Qatar University
Reham M. A. Aly: Qatar University
Muna Al Maslamani: Hamad Medical Corporation
Khalid Ouararhni: Hamad Bin Khalifa University, Qatar Foundation
Mohamad Y. Khatib: Hezm Mebairek General Hospital, Hamad Medical Corporation
Ali Ait Hssain: Hamad General Hospital, Hamad Medical Corporation
Ali S. Omrani: Hamad Medical Corporation
Saad Al-Kaabi: Hamad General Hospital, Hamad Medical Corporation
Abdullatif Al Khal: Hamad Medical Corporation
Asmaa A. Al-Thani: Qatar University
Waseem Samsam: Anti-Doping Laboratory Qatar
Abdulaziz Farooq: Aspetar Hospital, Orthopaedic and Sports Medicine Hospital, FIFA Medical Centre of Excellence
Jassim Al-Suwaidi: Hamad General Hospital, Hamad Medical Corporation
Mohammed Al-Maadheed: Royal Free Campus, University College London
Heba H. Al-Siddiqi: Hamad Bin Khalifa University, Qatar Foundation
Alexandra E. Butler: Hamad Bin Khalifa University, Qatar Foundation
Julie V. Decock: Hamad Bin Khalifa University, Qatar Foundation
Vidya Mohamed-Ali: Royal Free Campus, University College London
Fares Al-Ejeh: Hamad Bin Khalifa University, Qatar Foundation

Nature Communications, 2022, vol. 13, issue 1, 1-14

Abstract: Abstract COVID-19 complications still present a huge burden on healthcare systems and warrant predictive risk models to triage patients and inform early intervention. Here, we profile 893 plasma proteins from 50 severe and 50 mild-moderate COVID-19 patients, and 50 healthy controls, and show that 375 proteins are differentially expressed in the plasma of severe COVID-19 patients. These differentially expressed plasma proteins are implicated in the pathogenesis of COVID-19 and present targets for candidate drugs to prevent or treat severe complications. Based on the plasma proteomics and clinical lab tests, we also report a 12-plasma protein signature and a model of seven routine clinical tests that validate in an independent cohort as early risk predictors of COVID-19 severity and patient survival. The risk predictors and candidate drugs described in our study can be used and developed for personalized management of SARS-CoV-2 infected patients.

Date: 2022
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DOI: 10.1038/s41467-022-28639-4

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