Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP

María García-García, Sara Sánchez-Perales, Patricia Jarabo, Enrique Calvo, Trevor Huyton, Liran Fu, Sheung Chun Ng, Laura Sotodosos-Alonso, Jesús Vázquez, Sergio Casas-Tintó, Dirk Görlich, Asier Echarri () and Miguel A. Del Pozo ()
Additional contact information
María García-García: Centro Nacional de Investigaciones Cardiovasculares (CNIC)
Sara Sánchez-Perales: Centro Nacional de Investigaciones Cardiovasculares (CNIC)
Patricia Jarabo: Instituto Cajal-CSIC
Enrique Calvo: Centro Nacional de Investigaciones Cardiovasculares (CNIC)
Trevor Huyton: Max Planck Institute for Biophysical Chemistry
Liran Fu: Max Planck Institute for Biophysical Chemistry
Sheung Chun Ng: Max Planck Institute for Biophysical Chemistry
Laura Sotodosos-Alonso: Centro Nacional de Investigaciones Cardiovasculares (CNIC)
Jesús Vázquez: Centro Nacional de Investigaciones Cardiovasculares (CNIC)
Sergio Casas-Tintó: Instituto Cajal-CSIC
Dirk Görlich: Max Planck Institute for Biophysical Chemistry
Asier Echarri: Centro Nacional de Investigaciones Cardiovasculares (CNIC)
Miguel A. Del Pozo: Centro Nacional de Investigaciones Cardiovasculares (CNIC)

Nature Communications, 2022, vol. 13, issue 1, 1-21

Abstract: Abstract Mechanical forces regulate multiple essential pathways in the cell. The nuclear translocation of mechanoresponsive transcriptional regulators is an essential step for mechanotransduction. However, how mechanical forces regulate the nuclear import process is not understood. Here, we identify a highly mechanoresponsive nuclear transport receptor (NTR), Importin-7 (Imp7), that drives the nuclear import of YAP, a key regulator of mechanotransduction pathways. Unexpectedly, YAP governs the mechanoresponse of Imp7 by forming a YAP/Imp7 complex that responds to mechanical cues through the Hippo kinases MST1/2. Furthermore, YAP behaves as a dominant cargo of Imp7, restricting the Imp7 binding and the nuclear translocation of other Imp7 cargoes such as Smad3 and Erk2. Thus, the nuclear import process is an additional regulatory layer indirectly regulated by mechanical cues, which activate a preferential Imp7 cargo, YAP, which competes out other cargoes, resulting in signaling crosstalk.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-022-28693-y Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28693-y

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-28693-y

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().