Phase separation on cell surface facilitates bFGF signal transduction with heparan sulphate

Song Xue, Fan Zhou, Tian Zhao, Huimin Zhao, Xuewei Wang, Long Chen, Jin-ping Li and Shi-Zhong Luo ()
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Song Xue: Beijing University of Chemical Technology
Fan Zhou: Beijing University of Chemical Technology
Tian Zhao: Beijing University of Chemical Technology
Huimin Zhao: Beijing University of Chemical Technology
Xuewei Wang: Beijing University of Chemical Technology
Long Chen: Beijing University of Chemical Technology
Jin-ping Li: Beijing University of Chemical Technology
Shi-Zhong Luo: Beijing University of Chemical Technology

Nature Communications, 2022, vol. 13, issue 1, 1-10

Abstract: Abstract Liquid-liquid phase separation (LLPS) plays important roles in various cellular processes, facilitating membrane-less organelles construction, chromatin condensation, signal transduction on inner membrane and many other processes. Current perception is that LLPS relies on weak multivalent interactions and crowded environments intracellularly. In this study, we demonstrate that heparan sulfate can serve as a platform to induce the phase separation of basic fibroblast growth factor on cell surface. The phase separation model provides an alternative mechanism how bFGF is enriched to its receptors, therefore triggering the signaling transduction. The research provides insights on the mechanism how growth factors can be recruited to cell surface by heparan sulfate and execute their functions, extending people’s view on phase separation from intracellular to extracellular proteins at cellular level.

Date: 2022
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DOI: 10.1038/s41467-022-28765-z

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