Antibody escape and global spread of SARS-CoV-2 lineage A.27

Tamara Kaleta, Lisa Kern, Samuel Leandro Hong, Martin Hölzer, Georg Kochs, Julius Beer, Daniel Schnepf, Martin Schwemmle, Nena Bollen, Philipp Kolb, Magdalena Huber, Svenja Ulferts, Sebastian Weigang, Gytis Dudas, Alice Wittig, Lena Jaki, Abdou Padane, Adamou Lagare, Mounerou Salou, Egon Anderson Ozer, Ndodo Nnaemeka, John Kofi Odoom, Robert Rutayisire, Alia Benkahla, Chantal Akoua-Koffi, Abdoul-Salam Ouedraogo, Etienne Simon-Lorière, Vincent Enouf, Stefan Kröger, Sébastien Calvignac-Spencer, Guy Baele, Marcus Panning () and Jonas Fuchs ()
Additional contact information
Tamara Kaleta: University of Freiburg
Lisa Kern: University of Freiburg
Samuel Leandro Hong: Rega Institute, KU Leuven
Martin Hölzer: Robert Koch Institute
Georg Kochs: University of Freiburg
Julius Beer: University of Freiburg
Daniel Schnepf: University of Freiburg
Martin Schwemmle: University of Freiburg
Nena Bollen: Rega Institute, KU Leuven
Philipp Kolb: University of Freiburg
Magdalena Huber: University of Freiburg
Svenja Ulferts: University of Freiburg
Sebastian Weigang: University of Freiburg
Gytis Dudas: Gothenburg Global Biodiversity Centre
Alice Wittig: Robert Koch Institute
Lena Jaki: University of Freiburg
Abdou Padane: de Surveillance Epidémiologique et de Formation (IRESSEF)
Adamou Lagare: Centre de Recherche Médicale et Sanitaire (CERMES)
Mounerou Salou: Université de Lomé
Egon Anderson Ozer: Northwestern University Feinberg School of Medicine
Ndodo Nnaemeka: Nigeria Centre for Disease Control
John Kofi Odoom: Noguchi Memorial Institute for Medical Research, University of Ghana
Robert Rutayisire: Ministry of Health
Alia Benkahla: Institut Pasteur de Tunis, University of Tunis El Manar
Chantal Akoua-Koffi: Centre Hospitalier et Universitaire de Bouaké
Abdoul-Salam Ouedraogo: Souro Sanou University Hospital
Etienne Simon-Lorière: Institut Pasteur
Vincent Enouf: Institut Pasteur
Stefan Kröger: Robert Koch Institute
Sébastien Calvignac-Spencer: Robert Koch Institute
Guy Baele: Rega Institute, KU Leuven
Marcus Panning: University of Freiburg
Jonas Fuchs: University of Freiburg

Nature Communications, 2022, vol. 13, issue 1, 1-13

Abstract: Abstract In spring 2021, an increasing number of infections was observed caused by the hitherto rarely described SARS-CoV-2 variant A.27 in south-west Germany. From December 2020 to June 2021 this lineage has been detected in 31 countries. Phylogeographic analyses of A.27 sequences obtained from national and international databases reveal a global spread of this lineage through multiple introductions from its inferred origin in Western Africa. Variant A.27 is characterized by a mutational pattern in the spike gene that includes the L18F, L452R and N501Y spike amino acid substitutions found in various variants of concern but lacks the globally dominant D614G. Neutralization assays demonstrate an escape of A.27 from convalescent and vaccine-elicited antibody-mediated immunity. Moreover, the therapeutic monoclonal antibody Bamlanivimab and partially the REGN-COV2 cocktail fail to block infection by A.27. Our data emphasize the need for continued global monitoring of novel lineages because of the independent evolution of new escape mutations.

Date: 2022
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DOI: 10.1038/s41467-022-28766-y

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