Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica
Yue Hong (),
Shan Shan,
Ye Gu,
Haidong Huang,
Quncheng Zhang,
Yang Han,
Yongpin Dong,
Zeyu Liu,
Moli Huang and
Tao Ren ()
Additional contact information
Yue Hong: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Shan Shan: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Ye Gu: Tongji University Affiliated Shanghai Pulmonary Hospital
Haidong Huang: Changhai Hospital, The Second Military Medical University
Quncheng Zhang: Henan Provincial People’s Hospital
Yang Han: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Yongpin Dong: The Second Military Medical University
Zeyu Liu: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Moli Huang: Soochow University
Tao Ren: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Nature Communications, 2022, vol. 13, issue 1, 1-18
Abstract:
Abstract Understanding disease-associated stem cell abnormality has major clinical implications for prevention and treatment of human disorders, as well as for regenerative medicine. Here we report a multifaceted study on airway epithelial stem cells in Tracheobronchopathia Osteochondroplastica (TO), an under-detected tracheobronchial disorder of unknown etiology and lack of specific treatment. Epithelial squamous metaplasia and heterotopic bone formation with abnormal cartilage proliferation and calcium deposits are key pathological hallmarks of this disorder, but it is unknown whether they are coincident or share certain pathogenic mechanisms in common. By functional evaluation and genome-wide profiling at both transcriptional and epigenetic levels, we reveal a role of airway basal cells in TO progression by acting as a repository of inflammatory and TGFβ-BMP signals, which contributes to both epithelial metaplasia and mesenchymal osteo-chondrogenesis via extracellular signaling and matrix remodeling. Restoration of microenvironment by cell correction or local pathway intervention may provide therapeutic benefits.
Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)
Downloads: (external link)
https://www.nature.com/articles/s41467-022-28903-7 Abstract (text/html)
Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.
Export reference: BibTeX
RIS (EndNote, ProCite, RefMan)
HTML/Text
Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28903-7
Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/
DOI: 10.1038/s41467-022-28903-7
Access Statistics for this article
Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie
More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().