The flavonoid corylin exhibits lifespan extension properties in mouse

Tong-Hong Wang, Wei-Che Tseng, Yann-Lii Leu, Chi-Yuan Chen, Wen-Chih Lee, Ying-Chih Chi, Shu-Fang Cheng, Chun-Yu Lai, Chen-Hsin Kuo, Shu-Ling Yang, Sien-Hung Yang, Jiann-Jong Shen, Chun-Hao Feng, Chih-Ching Wu, Tsong-Long Hwang, Chia-Jen Wang, Shu-Huei Wang () and Chin-Chuan Chen ()
Additional contact information
Tong-Hong Wang: Tissue Bank, Chang Gung Memorial Hospital
Wei-Che Tseng: Chang Gung University
Yann-Lii Leu: Tissue Bank, Chang Gung Memorial Hospital
Chi-Yuan Chen: Tissue Bank, Chang Gung Memorial Hospital
Wen-Chih Lee: Tzu Chi University
Ying-Chih Chi: Columbia University Irving Medical Center
Shu-Fang Cheng: Chang Gung University
Chun-Yu Lai: Chang Gung University
Chen-Hsin Kuo: Chang Gung University
Shu-Ling Yang: Chang Gung University
Sien-Hung Yang: Chang Gung University
Jiann-Jong Shen: Chang Gung University
Chun-Hao Feng: Chang Gung University
Chih-Ching Wu: Chang Gung University
Tsong-Long Hwang: Chang Gung University of Science and Technology
Chia-Jen Wang: Chang Gung Memorial Hospital
Shu-Huei Wang: National Taiwan University
Chin-Chuan Chen: Tissue Bank, Chang Gung Memorial Hospital

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract In the long history of traditional Chinese medicine, single herbs and complex formulas have been suggested to increase lifespan. However, the identification of single molecules responsible for lifespan extension has been challenging. Here, we collected a list of traditional Chinese medicines with potential longevity properties from pharmacopeias. By utilizing the mother enrichment program, we systematically screened these traditional Chinese medicines and identified a single herb, Psoralea corylifolia, that increases lifespan in Saccharomyces cerevisiae. Next, twenty-two pure compounds were isolated from Psoralea corylifolia. One of the compounds, corylin, was found to extend the replicative lifespan in yeast by targeting the Gtr1 protein. In human umbilical vein endothelial cells, RNA sequencing data showed that corylin ameliorates cellular senescence. We also examined an in vivo mammalian model, and found that corylin extends lifespan in mice fed a high-fat diet. Taken together, these findings suggest that corylin may promote longevity.

Date: 2022
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DOI: 10.1038/s41467-022-28908-2

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