De novo inter-regional coactivations of preconfigured local ensembles support memory

Hiroyuki Miyawaki () and Kenji Mizuseki ()
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Hiroyuki Miyawaki: Osaka City University Graduate School of Medicine
Kenji Mizuseki: Osaka City University Graduate School of Medicine

Nature Communications, 2022, vol. 13, issue 1, 1-21

Abstract: Abstract Neuronal ensembles in the amygdala, ventral hippocampus, and prefrontal cortex are involved in fear memory; however, how inter-regional ensemble interactions support memory remains elusive. Using multi-regional large-scale electrophysiology in the aforementioned structures of fear-conditioned rats, we found that the local ensembles activated during fear memory acquisition are inter-regionally coactivated during the subsequent sleep period, which relied on brief bouts of fast network oscillations. During memory retrieval, the coactivations reappeared, together with fast oscillations. Coactivation-participating-ensembles were configured prior to memory acquisition in the amygdala and prefrontal cortex but developed through experience in the hippocampus. Our findings suggest that elements of a given memory are instantly encoded within various brain regions in a preconfigured manner, whereas hippocampal ensembles and the network for inter-regional integration of the distributed information develop in an experience-dependent manner to form a new memory, which is consistent with the hippocampal memory index hypothesis.

Date: 2022
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DOI: 10.1038/s41467-022-28929-x

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