Tunable and scalable fabrication of block copolymer-based 3D polymorphic artificial cell membrane array

Dong-Hyun Kang, Won Bae Han, Hyun Ryu, Nam Hyuk Kim, Tae Young Kim, Nakwon Choi, Ji Yoon Kang, Yeon Gyu Yu and Tae Song Kim ()
Additional contact information
Dong-Hyun Kang: Korea Institute of Science and Technology
Won Bae Han: Korea Institute of Science and Technology
Hyun Ryu: Korea Institute of Science and Technology
Nam Hyuk Kim: Kookmin University
Tae Young Kim: Korea Institute of Science and Technology
Nakwon Choi: Korea Institute of Science and Technology
Ji Yoon Kang: Korea Institute of Science and Technology
Yeon Gyu Yu: Kookmin University
Tae Song Kim: Korea Institute of Science and Technology

Nature Communications, 2022, vol. 13, issue 1, 1-11

Abstract: Abstract Owing to their excellent durability, tunable physical properties, and biofunctionality, block copolymer-based membranes provide a platform for various biotechnological applications. However, conventional approaches for fabricating block copolymer membranes produce only planar or suspended polymersome structures, which limits their utilization. This study is the first to demonstrate that an electric-field-assisted self-assembly technique can allow controllable and scalable fabrication of 3-dimensional block copolymer artificial cell membranes (3DBCPMs) immobilized on predefined locations. Topographically and chemically structured microwell array templates facilitate uniform patterning of block copolymers and serve as reactors for the effective growth of 3DBCPMs. Modulating the concentration of the block copolymer and the amplitude/frequency of the electric field generates 3DBCPMs with diverse shapes, controlled sizes, and high stability (100% survival over 50 days). In vitro protein–membrane assays and mimicking of human intestinal organs highlight the potential of 3DBCPMs for a variety of biological applications such as artificial cells, cell-mimetic biosensors, and bioreactors.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-022-28960-y Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28960-y

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-28960-y

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().