Gut microbiota and fermentation-derived branched chain hydroxy acids mediate health benefits of yogurt consumption in obese mice

Noëmie Daniel, Renato Tadeu Nachbar, Thi Thu Trang Tran, Adia Ouellette, Thibault Vincent Varin, Aurélie Cotillard, Laurent Quinquis, Andréanne Gagné, Philippe St-Pierre, Jocelyn Trottier, Bruno Marcotte, Marion Poirel, Mathilde Saccareau, Marie-Julie Dubois, Philippe Joubert, Olivier Barbier, Hana Koutnikova () and André Marette ()
Additional contact information
Noëmie Daniel: Laval University
Renato Tadeu Nachbar: Laval University
Thi Thu Trang Tran: Danone Nutricia Research
Adia Ouellette: Laval University
Thibault Vincent Varin: Laval University
Aurélie Cotillard: Danone Nutricia Research
Laurent Quinquis: Danone Nutricia Research
Andréanne Gagné: Laval University
Philippe St-Pierre: Laval University
Jocelyn Trottier: CHU of Québec Research Center and Faculty of Pharmacy
Bruno Marcotte: Laval University
Marion Poirel: IT&M Innovation on behalf of Danone Nutricia Research
Mathilde Saccareau: Soladis on behalf on Danone Nutricia Research
Marie-Julie Dubois: Laval University
Philippe Joubert: Laval University
Olivier Barbier: CHU of Québec Research Center and Faculty of Pharmacy
Hana Koutnikova: Danone Nutricia Research
André Marette: Laval University

Nature Communications, 2022, vol. 13, issue 1, 1-18

Abstract: Abstract Meta-analyses suggest that yogurt consumption reduces type 2 diabetes incidence in humans, but the molecular basis of these observations remains unknown. Here we show that dietary yogurt intake preserves whole-body glucose homeostasis and prevents hepatic insulin resistance and liver steatosis in a dietary mouse model of obesity-linked type 2 diabetes. Fecal microbiota transplantation studies reveal that these effects are partly linked to the gut microbiota. We further show that yogurt intake impacts the hepatic metabolome, notably maintaining the levels of branched chain hydroxy acids (BCHA) which correlate with improved metabolic parameters. These metabolites are generated upon milk fermentation and concentrated in yogurt. Remarkably, diet-induced obesity reduces plasma and tissue BCHA levels, and this is partly prevented by dietary yogurt intake. We further show that BCHA improve insulin action on glucose metabolism in liver and muscle cells, identifying BCHA as cell-autonomous metabolic regulators and potential mediators of yogurt’s health effects.

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29005-0

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DOI: 10.1038/s41467-022-29005-0

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