Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior

Li-Pao Fang, Na Zhao, Laura C. Caudal, Hsin-Fang Chang, Renping Zhao, Ching-Hsin Lin, Nadine Hainz, Carola Meier, Bernhard Bettler, Wenhui Huang, Anja Scheller, Frank Kirchhoff () and Xianshu Bai ()
Additional contact information
Li-Pao Fang: University of Saarland
Na Zhao: University of Saarland
Laura C. Caudal: University of Saarland
Hsin-Fang Chang: University of Saarland
Renping Zhao: University of Saarland
Ching-Hsin Lin: University of Saarland
Nadine Hainz: University of Saarland
Carola Meier: University of Saarland
Bernhard Bettler: University of Basel
Wenhui Huang: University of Saarland
Anja Scheller: University of Saarland
Frank Kirchhoff: University of Saarland
Xianshu Bai: University of Saarland

Nature Communications, 2022, vol. 13, issue 1, 1-14

Abstract: Abstract Cortical neural circuits are complex but very precise networks of balanced excitation and inhibition. Yet, the molecular and cellular mechanisms that form the balance are just beginning to emerge. Here, using conditional γ-aminobutyric acid receptor B1- deficient mice we identify a γ-aminobutyric acid/tumor necrosis factor superfamily member 12-mediated bidirectional communication pathway between parvalbumin-positive fast spiking interneurons and oligodendrocyte precursor cells that determines the density and function of interneurons in the developing medial prefrontal cortex. Interruption of the GABAergic signaling to oligodendrocyte precursor cells results in reduced myelination and hypoactivity of interneurons, strong changes of cortical network activities and impaired social cognitive behavior. In conclusion, glial transmitter receptors are pivotal elements in finetuning distinct brain functions.

Date: 2022
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DOI: 10.1038/s41467-022-29020-1

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