Harnessing phosphonate antibiotics argolaphos biosynthesis enables a synthetic biology-based green synthesis of glyphosate

Leixia Chu, Xiaoxia Luo, Taoting Zhu, Yingying Cao, Lili Zhang, Zixin Deng and Jiangtao Gao ()
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Leixia Chu: Fujian Agriculture and Forestry University
Xiaoxia Luo: Tarim University, Alar
Taoting Zhu: Fujian Agriculture and Forestry University
Yingying Cao: Fujian Agriculture and Forestry University
Lili Zhang: Fujian Agriculture and Forestry University
Zixin Deng: Shanghai Jiao Tong University
Jiangtao Gao: Fujian Agriculture and Forestry University

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract Glyphosate is a widely used herbicide with an annual production of more than one million tons globally. Current commercialized production processes of glyphosate are generally associated with manufacturing hazards and toxic wastes. Recently, many countries have strengthened environmental supervision and law enforcement on glyphosate manufacturing. Therefore, a green source of glyphosate is required. Here, we characterize the genes required for producing aminomethylphosphonate (AMP), one of the intermediates in the biosynthesis of the potent antibiotics argolaphos. We apply a synthetic biology strategy to improve AMP production in Streptomyces lividans, with fermentation titers of 52 mg L-1, a 500-fold improvement over the original strain. Furthermore, we develop an efficient and practical chemical process for converting AMP to glyphosate. Our findings highlight one greenness-driven alternative in the production of glyphosate.

Date: 2022
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DOI: 10.1038/s41467-022-29188-6

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