Identifying regions for enhanced control of gambiense sleeping sickness in the Democratic Republic of Congo

Ching-I Huang (), Ronald E. Crump, Paul E. Brown, Simon E. F. Spencer, Erick Mwamba Miaka, Chansy Shampa, Matt J. Keeling and Kat S. Rock
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Ching-I Huang: Zeeman Institute for System Biology and Infectious Disease Epidemiology Research, The University of Warwick
Ronald E. Crump: Zeeman Institute for System Biology and Infectious Disease Epidemiology Research, The University of Warwick
Paul E. Brown: Zeeman Institute for System Biology and Infectious Disease Epidemiology Research, The University of Warwick
Simon E. F. Spencer: Zeeman Institute for System Biology and Infectious Disease Epidemiology Research, The University of Warwick
Erick Mwamba Miaka: Programme National de Lutte contre la Trypanosomiase Humaine Africaine (PNLTHA)
Chansy Shampa: Programme National de Lutte contre la Trypanosomiase Humaine Africaine (PNLTHA)
Matt J. Keeling: Zeeman Institute for System Biology and Infectious Disease Epidemiology Research, The University of Warwick
Kat S. Rock: Zeeman Institute for System Biology and Infectious Disease Epidemiology Research, The University of Warwick

Nature Communications, 2022, vol. 13, issue 1, 1-11

Abstract: Abstract Gambiense human African trypanosomiasis (sleeping sickness, gHAT) is a disease targeted for elimination of transmission by 2030. While annual new cases are at a historical minimum, the likelihood of achieving the target is unknown. We utilised modelling to study the impacts of four strategies using currently available interventions, including active and passive screening and vector control, on disease burden and transmission across 168 endemic health zones in the Democratic Republic of the Congo. Median projected years of elimination of transmission show only 98 health zones are on track despite significant reduction in disease burden under medical-only strategies (64 health zones if > 90% certainty required). Blanket coverage with vector control is impractical, but is predicted to reach the target in all heath zones. Utilising projected disease burden under the uniform medical-only strategy, we provide a priority list of health zones for consideration for supplementary vector control alongside medical interventions.

Date: 2022
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DOI: 10.1038/s41467-022-29192-w

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