Acquiring new memories in neocortex of hippocampal-lesioned mice

Wenhan Luo, Di Yun, Yi Hu, Miaomiao Tian, Jiajun Yang, Yifan Xu, Yong Tang, Yang Zhan, Hong Xie and Ji-Song Guan ()
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Wenhan Luo: Shanghai Tech University
Di Yun: Shanghai Tech University
Yi Hu: Shanghai Tech University
Miaomiao Tian: Shanghai Tech University
Jiajun Yang: School of Life Sciences, Tsinghua University
Yifan Xu: School of Life Sciences, Tsinghua University
Yong Tang: Chinese Academy of Sciences
Yang Zhan: Chinese Academy of Sciences
Hong Xie: Institute of Photonic Chips, University of Shanghai for Science and Technology
Ji-Song Guan: Shanghai Tech University

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract The hippocampus interacts with the neocortical network for memory retrieval and consolidation. Here, we found the lateral entorhinal cortex (LEC) modulates learning-induced cortical long-range gamma synchrony (20–40 Hz) in a hippocampal-dependent manner. The long-range gamma synchrony, which was coupled to the theta (7–10 Hz) rhythm and enhanced upon learning and recall, was mediated by inter-cortical projections from layer 5 neurons of the LEC to layer 2 neurons of the sensory and association cortices. Artificially induced cortical gamma synchrony across cortical areas improved memory encoding in hippocampal lesioned mice for originally hippocampal-dependent tasks. Mechanistically, we found that activities of cortical c-Fos labeled neurons, which showed egocentric map properties, were modulated by LEC-mediated gamma synchrony during memory recall, implicating a role of cortical synchrony to generate an integrative memory representation from disperse features. Our findings reveal the hippocampal mediated organization of cortical memories and suggest brain-machine interface approaches to improve cognitive function.

Date: 2022
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DOI: 10.1038/s41467-022-29208-5

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