Serum proteomics links suppression of tumor immunity to ancestry and lethal prostate cancer

Tsion Zewdu Minas, Julián Candia, Tiffany H. Dorsey, Francine Baker, Wei Tang, Maeve Kiely, Cheryl J. Smith, Amy L. Zhang, Symone V. Jordan, Obadi M. Obadi, Anuoluwapo Ajao, Yao Tettey, Richard B. Biritwum, Andrew A. Adjei, James E. Mensah, Robert N. Hoover, Frank J. Jenkins, Rick Kittles, Ann W. Hsing, Xin W. Wang, Christopher A. Loffredo, Clayton Yates, Michael B. Cook and Stefan Ambs ()
Additional contact information
Tsion Zewdu Minas: National Cancer Institute, National Institutes of Health
Julián Candia: National Cancer Institute, National Institutes of Health
Tiffany H. Dorsey: National Cancer Institute, National Institutes of Health
Francine Baker: National Cancer Institute, National Institutes of Health
Wei Tang: National Cancer Institute, National Institutes of Health
Maeve Kiely: National Cancer Institute, National Institutes of Health
Cheryl J. Smith: National Cancer Institute, National Institutes of Health
Amy L. Zhang: National Cancer Institute, National Institutes of Health
Symone V. Jordan: National Cancer Institute, National Institutes of Health
Obadi M. Obadi: National Cancer Institute, National Institutes of Health
Anuoluwapo Ajao: National Cancer Institute, National Institutes of Health
Yao Tettey: University of Ghana Medical School
Richard B. Biritwum: University of Ghana Medical School
Andrew A. Adjei: University of Ghana Medical School
James E. Mensah: University of Ghana Medical School
Robert N. Hoover: National Cancer Institute, National Institutes of Health
Frank J. Jenkins: Hillman Cancer Center, University of Pittsburgh
Rick Kittles: City of Hope Comprehensive Cancer Center
Ann W. Hsing: Stanford Cancer Institute, Stanford School of Medicine
Xin W. Wang: National Cancer Institute, National Institutes of Health
Christopher A. Loffredo: Lombardi Comprehensive Cancer Center, Georgetown University Medical Center
Clayton Yates: Tuskegee University
Michael B. Cook: National Cancer Institute, National Institutes of Health
Stefan Ambs: National Cancer Institute, National Institutes of Health

Nature Communications, 2022, vol. 13, issue 1, 1-14

Abstract: Abstract There is evidence that tumor immunobiology and immunotherapy response may differ between African American and European American prostate cancer patients. Here, we determine if men of African descent harbor a unique systemic immune-oncological signature and measure 82 circulating proteins in almost 3000 Ghanaian, African American, and European American men. Protein signatures for suppression of tumor immunity and chemotaxis are elevated in men of West African ancestry. Importantly, the suppression of tumor immunity protein signature associates with metastatic and lethal prostate cancer, pointing to clinical importance. Moreover, two markers, pleiotrophin and TNFRSF9, predict poor disease survival specifically among African American men. These findings indicate that immune-oncology marker profiles differ between men of African and European descent. These differences may contribute to the disproportionate burden of lethal prostate cancer in men of African ancestry. The elevated peripheral suppression of tumor immunity may have important implication for guidance of cancer therapy which could particularly benefit African American patients.

Date: 2022
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DOI: 10.1038/s41467-022-29235-2

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