A hydrogen sulphide-responsive and depleting nanoplatform for cancer photodynamic therapy

Yuqi Zhang, Jing Fang, Shuyue Ye, Yan Zhao, Anna Wang, Qiulian Mao, Chaoxiang Cui, Yali Feng, Jiachen Li, Sunao Li, Mingyang Zhang and Haibin Shi ()
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Yuqi Zhang: Soochow University
Jing Fang: Soochow University
Shuyue Ye: Soochow University
Yan Zhao: Soochow University
Anna Wang: Soochow University
Qiulian Mao: Soochow University
Chaoxiang Cui: Soochow University
Yali Feng: Soochow University
Jiachen Li: Soochow University
Sunao Li: Soochow University
Mingyang Zhang: Soochow University
Haibin Shi: Soochow University

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract Hydrogen sulfide (H2S) as an important biological gasotransmitter plays a pivotal role in many physiological and pathological processes. The sensitive and quantitative detection of H2S level is therefore crucial for precise diagnosis and prognosis evaluation of various diseases but remains a huge challenge due to the lack of accurate and reliable analytical methods in vivo. In this work, we report a smart, H2S-responsive and depleting nanoplatform (ZNNPs) for quantitative and real-time imaging of endogenous H2S for early diagnosis and treatment of H2S-associated diseases. We show that ZNNPs exhibit unexpected NIR conversion (F1070 → F720) and ratiometric photoacoustic (PA680/PA900) signal responsiveness towards H2S, allowing for sensitive and quantitative visualization of H2S in acute hepatotoxicity, cerebral hemorrhage model as well as colorectal tumors in living mice. ZNNPs@FA simultaneously scavenges the mitochondrial H2S in tumors leading to significant ATP reduction and severe mitochondrial damage, together with the activated photodynamic effect, resulting in efficient suppression of colorectal tumor growth in mice. We believe that this platform may provide a powerful tool for studying the vital impacts of H2S in related diseases.

Date: 2022
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DOI: 10.1038/s41467-022-29284-7

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