Isolation of infectious Lloviu virus from Schreiber’s bats in Hungary

Gábor Kemenesi (), Gábor E. Tóth, Martin Mayora-Neto, Simon Scott, Nigel Temperton, Edward Wright, Elke Mühlberger, Adam J. Hume, Ellen L. Suder, Brigitta Zana, Sándor A. Boldogh, Tamás Görföl, Péter Estók, Tamara Szentiványi, Zsófia Lanszki, Balázs A. Somogyi, Ágnes Nagy, Csaba I. Pereszlényi, Gábor Dudás, Fanni Földes, Kornélia Kurucz, Mónika Madai, Safia Zeghbib, Piet Maes, Bert Vanmechelen and Ferenc Jakab
Additional contact information
Gábor Kemenesi: University of Pécs
Gábor E. Tóth: University of Pécs
Martin Mayora-Neto: Universities of Kent & Greenwich
Simon Scott: Universities of Kent & Greenwich
Nigel Temperton: Universities of Kent & Greenwich
Edward Wright: University of Sussex, Falmer
Elke Mühlberger: Boston University School of Medicine
Adam J. Hume: Boston University School of Medicine
Ellen L. Suder: Boston University School of Medicine
Brigitta Zana: University of Pécs
Sándor A. Boldogh: Aggtelek National Park Directorate
Tamás Görföl: University of Pécs
Péter Estók: Eszterházy Károly University
Tamara Szentiványi: Institute of Ecology and Botany, ÖK Centre for Ecological Research
Zsófia Lanszki: University of Pécs
Balázs A. Somogyi: University of Pécs
Ágnes Nagy: Hungarian Defence Forces
Csaba I. Pereszlényi: Hungarian Defence Forces
Gábor Dudás: Hungarian Defence Forces
Fanni Földes: University of Pécs
Kornélia Kurucz: University of Pécs
Mónika Madai: University of Pécs
Safia Zeghbib: University of Pécs
Piet Maes: Laboratory of Clinical and Epidemiological Virology
Bert Vanmechelen: Laboratory of Clinical and Epidemiological Virology
Ferenc Jakab: University of Pécs

Nature Communications, 2022, vol. 13, issue 1, 1-11

Abstract: Abstract Some filoviruses can be transmitted to humans by zoonotic spillover events from their natural host and filovirus outbreaks have occured with increasing frequency in the last years. The filovirus Lloviu virus (LLOV), was identified in 2002 in Schreiber’s bats (Miniopterus schreibersii) in Spain and was subsequently detected in bats in Hungary. Here we isolate infectious LLOV from the blood of a live sampled Schreiber’s bat in Hungary. The isolate is subsequently sequenced and cultured in the Miniopterus sp. kidney cell line SuBK12-08. It is furthermore able to infect monkey and human cells, suggesting that LLOV might have spillover potential. A multi-year surveillance of LLOV in bats in Hungary detects LLOV RNA in both deceased and live animals as well as in coupled ectoparasites from the families Nycteribiidae and Ixodidae. This correlates with LLOV seropositivity in sampled Schreiber’s bats. Our data support the role of bats, specifically Miniopterus schreibersii as hosts for LLOV in Europe. We suggest that bat-associated parasites might play a role in the natural ecology of filoviruses in temperate climate regions compared to filoviruses in the tropics.

Date: 2022
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DOI: 10.1038/s41467-022-29298-1

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