Comparative effectiveness and safety of homologous two-dose ChAdOx1 versus heterologous vaccination with ChAdOx1 and BNT162b2

Eduardo Hermosilla, Ermengol Coma, Junqing Xie, Shuo Feng, Carmen Cabezas, Leonardo Méndez-Boo, Francesc Fina, Elisabet Ballo, Montserrat Martínez, Manuel Medina-Peralta, Josep Maria Argimon and Daniel Prieto-Alhambra ()
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Eduardo Hermosilla: Generalitat de Catalunya
Ermengol Coma: Generalitat de Catalunya
Junqing Xie: University of Oxford
Shuo Feng: University of Oxford
Carmen Cabezas: Generalitat de Catalunya
Leonardo Méndez-Boo: Generalitat de Catalunya
Francesc Fina: Generalitat de Catalunya
Elisabet Ballo: Generalitat de Catalunya
Montserrat Martínez: Generalitat de Catalunya
Manuel Medina-Peralta: Generalitat de Catalunya
Josep Maria Argimon: Generalitat de Catalunya
Daniel Prieto-Alhambra: University of Oxford

Nature Communications, 2022, vol. 13, issue 1, 1-7

Abstract: Abstract Small trials have suggested that heterologous vaccination with first-dose ChAdOx1 and second-dose BNT162b2 may generate a better immune response than homologous vaccination with two doses of ChAdOx1. In this cohort analysis, we use linked data from Catalonia (Spain), where those aged

Date: 2022
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DOI: 10.1038/s41467-022-29301-9

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