Comparison of clonal architecture between primary and immunodeficient mouse-engrafted acute myeloid leukemia cells

Naomi Kawashima, Yuichi Ishikawa, Jeong Hui Kim, Yoko Ushijima, Akimi Akashi, Yohei Yamaguchi, Hikaru Hattori, Marie Nakashima, Seara Ikeno, Rika Kihara, Takahiro Nishiyama, Takanobu Morishita, Koichi Watamoto, Yukiyasu Ozawa, Kunio Kitamura and Hitoshi Kiyoi ()
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Naomi Kawashima: Nagoya University Graduate School of Medicine
Yuichi Ishikawa: Nagoya University Graduate School of Medicine
Jeong Hui Kim: Nagoya University Graduate School of Medicine
Yoko Ushijima: Nagoya University Graduate School of Medicine
Akimi Akashi: Nagoya University Graduate School of Medicine
Yohei Yamaguchi: Nagoya University Graduate School of Medicine
Hikaru Hattori: Nagoya University Graduate School of Medicine
Marie Nakashima: Nagoya University Graduate School of Medicine
Seara Ikeno: Nagoya University Graduate School of Medicine
Rika Kihara: Komaki City Hospital
Takahiro Nishiyama: Ichinomiya Municipal Hospital
Takanobu Morishita: Japanese Red Cross Nagoya First Hospital
Koichi Watamoto: Komaki City Hospital
Yukiyasu Ozawa: Japanese Red Cross Nagoya First Hospital
Kunio Kitamura: Ichinomiya Municipal Hospital
Hitoshi Kiyoi: Nagoya University Graduate School of Medicine

Nature Communications, 2022, vol. 13, issue 1, 1-11

Abstract: Abstract Patient-derived xenografts (PDX) are widely used as human cancer models. Previous studies demonstrated clonal discordance between PDX and primary cells. However, in acute myeloid leukemia (AML)-PDX models, the significance of the clonal dynamics occurring in PDX remains unclear. By evaluating changes in the variant allele frequencies (VAF) of somatic mutations in serial samples of paired primary AML and their PDX bone marrow cells, we identify the skewing engraftment of relapsed or refractory (R/R) AML clones in 57% of PDX models generated from multiclonal AML cells at diagnosis, even if R/R clones are minor at

Date: 2022
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DOI: 10.1038/s41467-022-29304-6

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