A hierarchical transcriptional network activates specific CDK inhibitors that regulate G2 to control cell size and number in Arabidopsis

Yuji Nomoto, Hirotomo Takatsuka, Kesuke Yamada, Toshiya Suzuki, Takamasa Suzuki, Ying Huang, David Latrasse, Jing An, Magdolna Gombos, Christian Breuer, Takashi Ishida, Kenichiro Maeo, Miyu Imamura, Takafumi Yamashino, Keiko Sugimoto, Zoltán Magyar, László Bögre, Cécile Raynaud, Moussa Benhamed and Masaki Ito ()
Additional contact information
Yuji Nomoto: Kanazawa University
Hirotomo Takatsuka: Kanazawa University
Kesuke Yamada: Kanazawa University
Toshiya Suzuki: National Institute of Genetics, 1111 Yata, Mishima
Takamasa Suzuki: Chubu University
Ying Huang: Université Paris-Saclay, CNRS, INRAE, Univ Evry, Institute of Plant Sciences Paris-Saclay (IPS2)
David Latrasse: Université Paris-Saclay, CNRS, INRAE, Univ Evry, Institute of Plant Sciences Paris-Saclay (IPS2)
Jing An: Université Paris-Saclay, CNRS, INRAE, Univ Evry, Institute of Plant Sciences Paris-Saclay (IPS2)
Magdolna Gombos: Institute of Plant Biology, Biological Research Centre
Christian Breuer: RIKEN Center for Sustainable Resource Science
Takashi Ishida: RIKEN Center for Sustainable Resource Science
Kenichiro Maeo: Nagoya University
Miyu Imamura: Nagoya University
Takafumi Yamashino: Nagoya University
Keiko Sugimoto: RIKEN Center for Sustainable Resource Science
Zoltán Magyar: Institute of Plant Biology, Biological Research Centre
László Bögre: Royal Holloway University of London
Cécile Raynaud: Université Paris-Saclay, CNRS, INRAE, Univ Evry, Institute of Plant Sciences Paris-Saclay (IPS2)
Moussa Benhamed: Université Paris-Saclay, CNRS, INRAE, Univ Evry, Institute of Plant Sciences Paris-Saclay (IPS2)
Masaki Ito: Kanazawa University

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract How cell size and number are determined during organ development remains a fundamental question in cell biology. Here, we identified a GRAS family transcription factor, called SCARECROW-LIKE28 (SCL28), with a critical role in determining cell size in Arabidopsis. SCL28 is part of a transcriptional regulatory network downstream of the central MYB3Rs that regulate G2 to M phase cell cycle transition. We show that SCL28 forms a dimer with the AP2-type transcription factor, AtSMOS1, which defines the specificity for promoter binding and directly activates transcription of a specific set of SIAMESE-RELATED (SMR) family genes, encoding plant-specific inhibitors of cyclin-dependent kinases and thus inhibiting cell cycle progression at G2 and promoting the onset of endoreplication. Through this dose-dependent regulation of SMR transcription, SCL28 quantitatively sets the balance between cell size and number without dramatically changing final organ size. We propose that this hierarchical transcriptional network constitutes a cell cycle regulatory mechanism that allows to adjust cell size and number to attain robust organ growth.

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29316-2

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DOI: 10.1038/s41467-022-29316-2

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