In vivo imaging of invasive aspergillosis with 18F-fluorodeoxysorbitol positron emission tomography

Dong-Yeon Kim, Ayoung Pyo, Sehyeon Ji, Sung-Hwan You, Seong Eun Kim, Daejin Lim, Heejung Kim, Kyung-Hwa Lee, Se-Jeong Oh, Ye-rim Jung, Uh Jin Kim, Subin Jeon, Seong Young Kwon, Sae-Ryung Kang, Hyang Burm Lee, Hoon Hyun, So-Young Kim, Kyung-Sub Moon, Sunwoo Lee, Seung Ji Kang () and Jung-Joon Min ()
Additional contact information
Dong-Yeon Kim: Gyeongsang National University
Ayoung Pyo: Chonnam National University Medical School and Hwasun Hospital
Sehyeon Ji: Chonnam National University Medical School
Sung-Hwan You: CNCure Biotech
Seong Eun Kim: Chonnam National University Medical School
Daejin Lim: Kangwon National University
Heejung Kim: Korea Institute of Radiological & Medical Sciences
Kyung-Hwa Lee: Chonnam National University Medical School
Se-Jeong Oh: Chonnam National University Medical School
Ye-rim Jung: Chonnam National University Medical School and Hwasun Hospital
Uh Jin Kim: Chonnam National University Medical School
Subin Jeon: Chonnam National University Medical School and Hwasun Hospital
Seong Young Kwon: Chonnam National University Medical School and Hwasun Hospital
Sae-Ryung Kang: Chonnam National University Medical School and Hwasun Hospital
Hyang Burm Lee: Chonnam National University
Hoon Hyun: Chonnam National University Medical School
So-Young Kim: CNCure Biotech
Kyung-Sub Moon: Chonnam National University Medical School
Sunwoo Lee: Chonnam National University
Seung Ji Kang: Chonnam National University Medical School
Jung-Joon Min: CNCure Biotech

Nature Communications, 2022, vol. 13, issue 1, 1-11

Abstract: Abstract Invasive aspergillosis is a critical complication in immunocompromised patients with hematologic malignancies or with viral pneumonia caused by influenza virus or SARS‑CoV‑2. Although early and accurate diagnosis of invasive aspergillosis can maximize clinical outcomes, current diagnostic methods are time-consuming and poorly sensitive. Here, we assess the ability of 2-deoxy-2-18F-fluorosorbitol (18F-FDS) positron emission tomography (PET) to specifically and noninvasively detect Aspergillus infections. We show that 18F-FDS PET can be used to visualize Aspergillus fumigatus infection of the lungs, brain, and muscles in mouse models. In particular, 18F-FDS can distinguish pulmonary aspergillosis from Staphylococcus aureus infection, both of which induce pulmonary infiltrates in immunocompromised patients. Thus, our results indicate that the combination of 18F-FDS PET and appropriate clinical information may be useful in the differential diagnosis and localization of invasive aspergillosis.

Date: 2022
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DOI: 10.1038/s41467-022-29553-5

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