Construction of emissive ruthenium(II) metallacycle over 1000 nm wavelength for in vivo biomedical applications

Yuling Xu, Chonglu Li, Shuai Lu, Zhizheng Wang, Shuang Liu, Xiujun Yu, Xiaopeng Li () and Yao Sun ()
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Yuling Xu: Central China Normal University
Chonglu Li: Central China Normal University
Shuai Lu: Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen
Zhizheng Wang: Central China Normal University
Shuang Liu: Wuhan University of Technology
Xiujun Yu: Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen
Xiaopeng Li: Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen
Yao Sun: Central China Normal University

Nature Communications, 2022, vol. 13, issue 1, 1-13

Abstract: Abstract Although Ru(II)-based agents are expected to be promising candidates for substituting Pt-drug, their in vivo biomedical applications are still limited by the short excitation/emission wavelengths and unsatisfactory therapeutic efficiency. Herein, we rationally design a Ru(II) metallacycle with excitation at 808 nm and emission over 1000 nm, namely Ru1085, which holds deep optical penetration (up to 6 mm) and enhanced chemo-phototherapy activity. In vitro studies indicate that Ru1085 exhibits prominent cell uptake and desirable anticancer capability against various cancer cell lines, especially for cisplatin-resistant A549 cells. Further studies reveal Ru1085 induces mitochondria-mediated apoptosis along with S and G2/M phase cell cycle arrest. Finally, Ru1085 shows precise NIR-II fluorescence imaging guided and long-term monitored chemo-phototherapy against A549 tumor with minimal side effects. We envision that the design of long-wavelength emissive metallacycle will offer emerging opportunities of metal-based agents for in vivo biomedical applications.

Date: 2022
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DOI: 10.1038/s41467-022-29572-2

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