Protection following BNT162b2 booster in adolescents substantially exceeds that of a fresh 2-dose vaccine

Ofra Amir, Yair Goldberg (), Micha Mandel, Yinon M. Bar-On, Omri Bodenheimer, Nachman Ash, Sharon Alroy-Preis, Amit Huppert and Ron Milo
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Ofra Amir: Technion—Israel Institute of Technology
Yair Goldberg: Technion—Israel Institute of Technology
Micha Mandel: The Hebrew University of Jerusalem
Yinon M. Bar-On: Weizmann Institute of Science
Omri Bodenheimer: Israel Ministry of Health
Nachman Ash: Israel Ministry of Health
Sharon Alroy-Preis: Israel Ministry of Health
Amit Huppert: The Bio-statistical and Bio-mathematical Unit, The Gertner Institute for Epidemiology & Health Policy Research, Sheba Medical Center
Ron Milo: Weizmann Institute of Science

Nature Communications, 2022, vol. 13, issue 1, 1-5

Abstract: Abstract Israel began administering a BNT162b2 booster dose to restore protection following the waning of the 2-dose vaccine. Biological studies have shown that a “fresh” booster dose leads to increased antibody levels compared to a fresh 2-dose vaccine, which may suggest increased effectiveness. To compare the real-world effectiveness of a fresh (up to 60 days) booster dose with that of a fresh 2-dose vaccine, we took advantage of a quasi-experimental study that compares populations that were eligible to receive the vaccine at different times due to age-dependent policies. Specifically, we compared the confirmed infection rates in adolescents aged 12–14 (215,653 individuals) who received the 2-dose vaccine and in adolescents aged 16–18 (103,454 individuals) who received the booster dose. Our analysis shows that the confirmed infection rate was lower by a factor of 3.7 (95% CI: 2.7 to 5.2) in the booster group.

Date: 2022
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DOI: 10.1038/s41467-022-29578-w

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