Carbonized paramagnetic complexes of Mn (II) as contrast agents for precise magnetic resonance imaging of sub-millimeter-sized orthotopic tumors

Ruixue Qin, Shi Li, Yuwei Qiu, Yushuo Feng, Yaqing Liu, Dandan Ding, Lihua Xu, Xiaoqian Ma, Wenjing Sun and Hongmin Chen ()
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Ruixue Qin: School of Public Health, Xiamen University
Shi Li: School of Public Health, Xiamen University
Yuwei Qiu: School of Public Health, Xiamen University
Yushuo Feng: School of Public Health, Xiamen University
Yaqing Liu: School of Public Health, Xiamen University
Dandan Ding: School of Public Health, Xiamen University
Lihua Xu: School of Public Health, Xiamen University
Xiaoqian Ma: School of Public Health, Xiamen University
Wenjing Sun: School of Public Health, Xiamen University
Hongmin Chen: School of Public Health, Xiamen University

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract Paramagnetic complexes containing gadolinium ions have been widely used for magnetic resonance imaging (MRI) in clinic. However, these paramagnetic complexes pose some safety concerns. There is still a demand for the development of stable MRI contrast agents that exhibit higher sensitivity and superior functionality to existing contrast agents. Here, we develop carbonized paramagnetic complexes of manganese (II) (Mn@CCs) to encapsulate Mn2+ in sealed carbonized shells with superhigh r1 relaxivity. Compared to the most common clinical contrast agent Magnevist, investigations in vivo demonstrate that the Mn@CCs cross the intact blood-brain barrier of normal health mice with minor metal deposition; preferentially target the glioma tissues distribute homogeneously with high penetration in an intracranial mouse model; delineate clear tumor margins in MRIs of ultrasmall single-nodule brain tumors, and multi-nodular liver tumors. The sensitivity, accuracy and low toxicity offer by Mn@CCs provides new opportunities for early molecular diagnostics and imaging-guided biomedical applications.

Date: 2022
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DOI: 10.1038/s41467-022-29586-w

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