Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice

Mengci Li, Shouli Wang, Yitao Li, Mingliang Zhao, Junliang Kuang, Dandan Liang, Jieyi Wang, Meilin Wei, Cynthia Rajani, Xinran Ma, Yajun Tang, Zhenxing Ren, Tianlu Chen, Aihua Zhao, Cheng Hu, Chengxing Shen, Weiping Jia, Ping Liu, Xiaojiao Zheng () and Wei Jia ()
Additional contact information
Mengci Li: Shanghai Jiao Tong University
Shouli Wang: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Yitao Li: Hong Kong Baptist University
Mingliang Zhao: Shanghai Jiao Tong University
Junliang Kuang: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Dandan Liang: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Jieyi Wang: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Meilin Wei: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Cynthia Rajani: University of Hawaii Cancer Center
Xinran Ma: East China Normal University
Yajun Tang: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Zhenxing Ren: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Tianlu Chen: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Aihua Zhao: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Cheng Hu: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute
Chengxing Shen: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Weiping Jia: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute
Ping Liu: Shanghai Jiao Tong University
Xiaojiao Zheng: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Wei Jia: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract Calorie restriction (CR) and fasting are common approaches to weight reduction, but the maintenance is difficult after resuming food consumption. Meanwhile, the gut microbiome associated with energy harvest alters dramatically in response to nutrient deprivation. Here, we reported that CR and high-fat diet (HFD) both remodeled the gut microbiota with similar microbial composition, Parabacteroides distasonis was most significantly decreased after CR or HFD. CR altered microbiota and reprogramed metabolism, resulting in a distinct serum bile acid profile characterized by depleting the proportion of non-12α-hydroxylated bile acids, ursodeoxycholic acid and lithocholic acid. Downregulation of UCP1 expression in brown adipose tissue and decreased serum GLP-1 were observed in the weight-rebound mice. Moreover, treatment with Parabacteroides distasonis or non-12α-hydroxylated bile acids ameliorated weight regain via increased thermogenesis. Our results highlighted the gut microbiota-bile acid crosstalk in rebound weight gain and Parabacteroides distasonis as a potential probiotic to prevent rapid post-CR weight gain.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-022-29589-7 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29589-7

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-29589-7

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().