Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic

Livia V. Patrono, Bram Vrancken, Matthias Budt, Ariane Düx, Sebastian Lequime, Sengül Boral, M. Thomas P. Gilbert, Jan F. Gogarten, Luisa Hoffmann, David Horst, Kevin Merkel, David Morens, Baptiste Prepoint, Jasmin Schlotterbeck, Verena J. Schuenemann, Marc A. Suchard, Jeffery K. Taubenberger, Luisa Tenkhoff, Christian Urban, Navena Widulin, Eduard Winter, Michael Worobey, Thomas Schnalke, Thorsten Wolff, Philippe Lemey and Sébastien Calvignac-Spencer ()
Additional contact information
Livia V. Patrono: Robert Koch Institute
Bram Vrancken: KU Leuven
Matthias Budt: Robert Koch Institute
Ariane Düx: Robert Koch Institute
Sebastian Lequime: University of Groningen
Sengül Boral: Institute for Pathology
M. Thomas P. Gilbert: University of Copenhagen
Jan F. Gogarten: Robert Koch Institute
Luisa Hoffmann: Robert Koch Institute
David Horst: Institute for Pathology
Kevin Merkel: Robert Koch Institute
David Morens: National Institute of Allergy and Infectious Diseases
Baptiste Prepoint: Robert Koch Institute
Jasmin Schlotterbeck: Robert Koch Institute
Verena J. Schuenemann: University of Zurich
Marc A. Suchard: University of California, Los Angeles
Jeffery K. Taubenberger: National Institute of Allergy and Infectious Diseases
Luisa Tenkhoff: Robert Koch Institute
Christian Urban: University of Zurich
Navena Widulin: Berlin Museum of Medical History
Eduard Winter: Natural History Museum of Vienna
Michael Worobey: University of Arizona
Thomas Schnalke: Berlin Museum of Medical History
Thorsten Wolff: Robert Koch Institute
Philippe Lemey: KU Leuven
Sébastien Calvignac-Spencer: Robert Koch Institute

Nature Communications, 2022, vol. 13, issue 1, 1-9

Abstract: Abstract The 1918 influenza pandemic was the deadliest respiratory pandemic of the 20th century and determined the genomic make-up of subsequent human influenza A viruses (IAV). Here, we analyze both the first 1918 IAV genomes from Europe and the first from samples prior to the autumn peak. 1918 IAV genomic diversity is consistent with a combination of local transmission and long-distance dispersal events. Comparison of genomes before and during the pandemic peak shows variation at two sites in the nucleoprotein gene associated with resistance to host antiviral response, pointing at a possible adaptation of 1918 IAV to humans. Finally, local molecular clock modeling suggests a pure pandemic descent of seasonal H1N1 IAV as an alternative to the hypothesis of origination through an intrasubtype reassortment.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-022-29614-9 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29614-9

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-29614-9

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().