A single-cell nanocoating of probiotics for enhanced amelioration of antibiotic-associated diarrhea

Jiezhou Pan, Guidong Gong, Qin Wang, Jiaojiao Shang, Yunxiang He, Chelsea Catania, Dan Birnbaum, Yifei Li, Zhijun Jia, Yaoyao Zhang (), Neel S. Joshi () and Junling Guo ()
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Jiezhou Pan: BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, West China Second University Hospital, Sichuan University
Guidong Gong: BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, West China Second University Hospital, Sichuan University
Qin Wang: School of Pharmacy, Southwest Minzu University
Jiaojiao Shang: BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, West China Second University Hospital, Sichuan University
Yunxiang He: BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, West China Second University Hospital, Sichuan University
Chelsea Catania: Massachusetts Institute of Technology
Dan Birnbaum: Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University
Yifei Li: BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, West China Second University Hospital, Sichuan University
Zhijun Jia: BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, West China Second University Hospital, Sichuan University
Yaoyao Zhang: BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, West China Second University Hospital, Sichuan University
Neel S. Joshi: Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University
Junling Guo: BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, West China Second University Hospital, Sichuan University

Nature Communications, 2022, vol. 13, issue 1, 1-11

Abstract: Abstract The gut microbiota represents a large community of microorganisms that play an important role in immune regulation and maintenance of homeostasis. Living bacteria receive increasing interest as potential therapeutics for gut disorders, because they inhibit the colonization of pathogens and positively regulate the composition of bacteria in gut. However, these treatments are often accompanied by antibiotic administration targeting pathogens. In these cases, the efficacy of therapeutic bacteria is compromised by their susceptibility to antibiotics. Here, we demonstrate that a single-cell coating composed of tannic acids and ferric ions, referred to as ‘nanoarmor’, can protect bacteria from the action of antibiotics. The nanoarmor protects both Gram-positive and Gram-negative bacteria against six clinically relevant antibiotics. The multiple interactions between the nanoarmor and antibiotic molecules allow the antibiotics to be effectively absorbed onto the nanoarmor. Armored probiotics have shown the ability to colonize inside the gastrointestinal tracts of levofloxacin-treated rats, which significantly reduced antibiotic-associated diarrhea (AAD) resulting from the levofloxacin-treatment and improved some of the pre-inflammatory symptoms caused by AAD. This nanoarmor strategy represents a robust platform to enhance the potency of therapeutic bacteria in the gastrointestinal tracts of patients receiving antibiotics and to avoid the negative effects of antibiotics in the gastrointestinal tract.

Date: 2022
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DOI: 10.1038/s41467-022-29672-z

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