Emergence of novel cephalopod gene regulation and expression through large-scale genome reorganization

Hannah Schmidbaur, Akane Kawaguchi, Tereza Clarence, Xiao Fu, Oi Pui Hoang, Bob Zimmermann, Elena A. Ritschard, Anton Weissenbacher, Jamie S. Foster, Spencer V. Nyholm, Paul A. Bates, Caroline B. Albertin (), Elly Tanaka () and Oleg Simakov ()
Additional contact information
Hannah Schmidbaur: University of Vienna
Akane Kawaguchi: Institute for Molecular Pathology
Tereza Clarence: The Francis Crick Institute
Xiao Fu: The Francis Crick Institute
Oi Pui Hoang: University of Vienna
Bob Zimmermann: University of Vienna
Elena A. Ritschard: University of Vienna
Anton Weissenbacher: Vienna Zoo
Jamie S. Foster: University of Florida, Space Life Science Lab
Spencer V. Nyholm: University of Connecticut
Paul A. Bates: The Francis Crick Institute
Caroline B. Albertin: Marine Biological Laboratory
Elly Tanaka: Institute for Molecular Pathology
Oleg Simakov: University of Vienna

Nature Communications, 2022, vol. 13, issue 1, 1-11

Abstract: Abstract Coleoid cephalopods (squid, cuttlefish, octopus) have the largest nervous system among invertebrates that together with many lineage-specific morphological traits enables complex behaviors. The genomic basis underlying these innovations remains unknown. Using comparative and functional genomics in the model squid Euprymna scolopes, we reveal the unique genomic, topological, and regulatory organization of cephalopod genomes. We show that coleoid cephalopod genomes have been extensively restructured compared to other animals, leading to the emergence of hundreds of tightly linked and evolutionary unique gene clusters (microsyntenies). Such novel microsyntenies correspond to topological compartments with a distinct regulatory structure and contribute to complex expression patterns. In particular, we identify a set of microsyntenies associated with cephalopod innovations (MACIs) broadly enriched in cephalopod nervous system expression. We posit that the emergence of MACIs was instrumental to cephalopod nervous system evolution and propose that microsyntenic profiling will be central to understanding cephalopod innovations.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-022-29694-7 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29694-7

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-29694-7

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().