T follicular helper and B cell crosstalk in tertiary lymphoid structures and cancer immunotherapy

Soizic Garaud, Marie-Caroline Dieu-Nosjean and Karen Willard-Gallo ()
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Soizic Garaud: Université Libre de Bruxelles
Marie-Caroline Dieu-Nosjean: Sorbonne University UMRS1135, Inserm U1135, Laboratory “Immune microenvironment and immunotherapy”, Centre d’Immunologie et des Maladies Infectieuses Paris (CIMI-Paris)
Karen Willard-Gallo: Université Libre de Bruxelles

Nature Communications, 2022, vol. 13, issue 1, 1-4

Abstract: Tumor-infiltrating lymphocytes (TILs) are critical in the elimination of cancer cells, a concept highlighted by recent advances in cancer immunotherapy. Significant evidence reveals that their organization in tertiary lymphoid structures together with specific subpopulation composition/balances stimulates cellular crosstalk and anti-tumor immunity in patients.

Date: 2022
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DOI: 10.1038/s41467-022-29753-z

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