Boron encapsulated in a liposome can be used for combinational neutron capture therapy

Jiyuan Li, Qi Sun, Chuanjie Lu, Han Xiao, Zhibin Guo, Dongban Duan, Zizhu Zhang, Tong Liu and Zhibo Liu ()
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Jiyuan Li: Peking University
Qi Sun: Peking University-Tsinghua University Center for Life Sciences
Chuanjie Lu: Peking University
Han Xiao: University of Chinese Academy of Sciences Beijing
Zhibin Guo: Peking University
Dongban Duan: Peking University
Zizhu Zhang: Beijing Nuclear Industry Hospital
Tong Liu: Beijing Capture Tech Co., Ltd
Zhibo Liu: Peking University

Nature Communications, 2022, vol. 13, issue 1, 1-11

Abstract: Abstract Boron neutron capture therapy (BNCT) is an attractive approach to treat invasive malignant tumours due to binary heavy-particle irradiation, but its clinical applications have been hindered by boron delivery agents with low in vivo stability, poor biocompatibility, and limited application of combinational modalities. Here, we report boronsome, a carboranyl-phosphatidylcholine based liposome for combinational BNCT and chemotherapy. Theoretical simulations and experimental approaches illustrate high stability of boronsome. Then positron emission tomography (PET) imaging with Cu-64 labelled boronsome reveals high-specific tumour accumulation and long retention with a clear irradiation background. In particular, we show the suppression of tumour growth treated with boronsome with neutron irradiation and therapeutic outcomes are further improved by encapsulation of chemotherapy drugs, especially with PARP1 inhibitors. In sum, boronsome may be an efficient agent for concurrent chemoradiotherapy with theranostic properties against malignancies.

Date: 2022
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DOI: 10.1038/s41467-022-29780-w

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