Accelerated biological aging in COVID-19 patients

Xue Cao, Wenjuan Li, Ting Wang, Dongzhi Ran, Veronica Davalos, Laura Planas-Serra, Aurora Pujol, Manel Esteller, Xiaolin Wang and Huichuan Yu ()
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Xue Cao: Guizhou Provincial People’s Hospital
Wenjuan Li: The Third Affiliated Hospital, Sun Yat-sen University
Ting Wang: Thermo Fisher Scientific Inc.
Dongzhi Ran: College of Medicine, University of Arizona
Veronica Davalos: Josep Carreras Leukaemia Research Institute (IJC)
Laura Planas-Serra: Bellvitge Biomedical Research Institute (IDIBELL)
Aurora Pujol: Bellvitge Biomedical Research Institute (IDIBELL)
Manel Esteller: Josep Carreras Leukaemia Research Institute (IJC)
Xiaolin Wang: Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital, Sun Yat-sen University
Huichuan Yu: Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital, Sun Yat-sen University

Nature Communications, 2022, vol. 13, issue 1, 1-7

Abstract: Abstract Chronological age is a risk factor for SARS-CoV-2 infection and severe COVID-19. Previous findings indicate that epigenetic age could be altered in viral infection. However, the epigenetic aging in COVID-19 has not been well studied. In this study, DNA methylation of the blood samples from 232 healthy individuals and 413 COVID-19 patients is profiled using EPIC methylation array. Epigenetic ages of each individual are determined by applying epigenetic clocks and telomere length estimator to the methylation profile of the individual. Epigenetic age acceleration is calculated and compared between groups. We observe strong correlations between the epigenetic clocks and individual’s chronological age (r > 0.8, p

Date: 2022
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DOI: 10.1038/s41467-022-29801-8

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