Information normally considered task-irrelevant drives decision-making and affects premotor circuit recruitment

Drew C. Schreiner, Christian Cazares, Rafael Renteria and Christina M. Gremel ()
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Drew C. Schreiner: University of California San Diego
Christian Cazares: University of California San Diego
Rafael Renteria: University of California San Diego
Christina M. Gremel: University of California San Diego

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract Decision-making is a continuous and dynamic process with prior experience reflected in and used by the brain to guide adaptive behavior. However, most neurobiological studies constrain behavior and/or analyses to task-related variables, not accounting for the continuous internal and temporal space in which they occur. We show mice rely on information learned through recent and longer-term experience beyond just prior actions and reward - including checking behavior and the passage of time - to guide self-initiated, self-paced, and self-generated actions. These experiences are represented in secondary motor cortex (M2) activity and its projections into dorsal medial striatum (DMS). M2 integrates this information to bias strategy-level decision-making, and DMS projections reflect specific aspects of this recent experience to guide actions. This suggests diverse aspects of experience drive decision-making and its neural representation, and shows premotor corticostriatal circuits are crucial for using selective aspects of experiential information to guide adaptive behavior.

Date: 2022
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DOI: 10.1038/s41467-022-29807-2

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