An unexpected strategy to alleviate hypoxia limitation of photodynamic therapy by biotinylation of photosensitizers
Jing An,
Shanliang Tang,
Gaobo Hong,
Wenlong Chen,
Miaomiao Chen,
Jitao Song,
Zhiliang Li,
Xiaojun Peng,
Fengling Song () and
Wen-Heng Zheng ()
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Jing An: Dalian University of Technology
Shanliang Tang: Dalian University of Technology
Gaobo Hong: Dalian University of Technology
Wenlong Chen: Dalian University of Technology
Miaomiao Chen: Dalian University of Technology
Jitao Song: Shandong University
Zhiliang Li: Shandong University
Xiaojun Peng: Dalian University of Technology
Fengling Song: Dalian University of Technology
Wen-Heng Zheng: Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital and Institute
Nature Communications, 2022, vol. 13, issue 1, 1-10
Abstract:
Abstract The most common working mechanism of photodynamic therapy is based on high-toxicity singlet oxygen, which is called Type II photodynamic therapy. But it is highly dependent on oxygen consumption. Recently, Type I photodynamic therapy has been found to have better hypoxia tolerance to ease this restriction. However, few strategies are available on the design of Type I photosensitizers. We herein report an unexpected strategy to alleviate the limitation of traditional photodynamic therapy by biotinylation of three photosensitizers (two fluorescein-based photosensitizers and the commercially available Protoporphyrin). The three biotiylated photosensitizers named as compound 1, 2 and 3, exhibit impressive ability in generating both superoxide anion radicals and singlet oxygen. Moreover, compound 1 can be activated upon low-power white light irradiation with stronger ability of anion radicals generation than the other two. The excellent combinational Type I / Type II photodynamic therapy performance has been demonstrated with the photosensitizers 1. This work presents a universal protocol to provide tumor-targeting ability and enhance or trigger the generation of anion radicals by biotinylation of Type II photosensitizers against tumor hypoxia.
Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29862-9
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DOI: 10.1038/s41467-022-29862-9
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