Mesoscopic landscape of cortical functions revealed by through-skull wide-field optical imaging in marmoset monkeys

Xindong Song (), Yueqi Guo, Hongbo Li, Chenggang Chen, Jong Hoon Lee, Yang Zhang, Zachary Schmidt and Xiaoqin Wang ()
Additional contact information
Xindong Song: Johns Hopkins University School of Medicine
Yueqi Guo: Johns Hopkins University School of Medicine
Hongbo Li: Johns Hopkins University School of Medicine
Chenggang Chen: Johns Hopkins University School of Medicine
Jong Hoon Lee: Johns Hopkins University School of Medicine
Yang Zhang: Johns Hopkins University School of Medicine
Zachary Schmidt: Johns Hopkins University School of Medicine
Xiaoqin Wang: Johns Hopkins University School of Medicine

Nature Communications, 2022, vol. 13, issue 1, 1-19

Abstract: Abstract The primate cerebral cortex is organized into specialized areas representing different modalities and functions along a continuous surface. The functional maps across the cortex, however, are often investigated a single modality at a time (e.g., audition or vision). To advance our understanding of the complex landscape of primate cortical functions, here we develop a polarization-gated wide-field optical imaging method for measuring cortical functions through the un-thinned intact skull in awake marmoset monkeys (Callithrix jacchus), a primate species featuring a smooth cortex. Using this method, adjacent auditory, visual, and somatosensory cortices are noninvasively parcellated in individual subjects with detailed tonotopy, retinotopy, and somatotopy. An additional pure-tone-responsive tonotopic gradient is discovered in auditory cortex and a face-patch sensitive to motion in the lower-center visual field is localized near an auditory region representing frequencies of conspecific vocalizations. This through-skull landscape-mapping approach provides new opportunities for understanding how the primate cortex is organized and coordinated to enable real-world behaviors.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-022-29864-7 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29864-7

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-29864-7

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().