Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex

Sofie L. Valk (), Ting Xu, Casey Paquola, Bo-yong Park, Richard A. I. Bethlehem, Reinder Vos de Wael, Jessica Royer, Shahrzad Kharabian Masouleh, Şeyma Bayrak, Peter Kochunov, B. T. Thomas Yeo, Daniel Margulies, Jonathan Smallwood, Simon B. Eickhoff and Boris C. Bernhardt
Additional contact information
Sofie L. Valk: Max Planck Institute for Human Cognitive and Brain Sciences
Ting Xu: Center for the Developing Brain, Child Mind Institute
Casey Paquola: McGill University
Bo-yong Park: McGill University
Richard A. I. Bethlehem: Cambridge University
Reinder Vos de Wael: McGill University
Jessica Royer: McGill University
Shahrzad Kharabian Masouleh: FZ Jülich
Şeyma Bayrak: Max Planck Institute for Human Cognitive and Brain Sciences
Peter Kochunov: Department of Psychiatry, University of Maryland School of Medicine
B. T. Thomas Yeo: National University of Singapore
Daniel Margulies: Institut de Cerveau et de la Moelle epiniere
Jonathan Smallwood: Queen’s University
Simon B. Eickhoff: FZ Jülich
Boris C. Bernhardt: McGill University

Nature Communications, 2022, vol. 13, issue 1, 1-17

Abstract: Abstract Brain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. However, it remains unclear how a static, genetically controlled architecture supports flexible cognition and behavior. Here, we synthesize genetic, phylogenetic and cognitive analyses to understand how the macroscale organization of structure-function coupling across the cortex can inform its role in cognition. In humans, structure-function coupling was highest in regions of unimodal cortex and lowest in transmodal cortex, a pattern that was mirrored by a reduced alignment with heritable connectivity profiles. Structure-function uncoupling in macaques had a similar spatial distribution, but we observed an increased coupling between structure and function in association cortices relative to humans. Meta-analysis suggested regions with the least genetic control (low heritable correspondence and different across primates) are linked to social-cognition and autobiographical memory. Our findings suggest that genetic and evolutionary uncoupling of structure and function in different transmodal systems may support the emergence of complex forms of cognition.

Date: 2022
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DOI: 10.1038/s41467-022-29886-1

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