ON/OFF domains shape receptive field structure in mouse visual cortex

Elaine Tring, Konnie K. Duan and Dario L. Ringach ()
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Elaine Tring: David Geffen School of Medicine, UCLA
Konnie K. Duan: Harvard-Westlake School
Dario L. Ringach: David Geffen School of Medicine, UCLA

Nature Communications, 2022, vol. 13, issue 1, 1-11

Abstract: Abstract In higher mammals, thalamic afferents to primary visual cortex (area V1) segregate according to their responses to increases (ON) or decreases (OFF) in luminance. This organization induces columnar, ON/OFF domains postulated to provide a scaffold for the emergence of orientation tuning. To further test this idea, we asked whether ON/OFF domains exist in mouse V1. Here we show that mouse V1 is indeed parceled into ON/OFF domains. Interestingly, fluctuations in the relative density of ON/OFF neurons on the cortical surface mirror fluctuations in the relative density of ON/OFF receptive field centers on the visual field. Moreover, the local diversity of cortical receptive fields is explained by a model in which neurons linearly combine a small number of ON and OFF signals available in their cortical neighborhoods. These findings suggest that ON/OFF domains originate in fluctuations of the balance between ON/OFF responses across the visual field which, in turn, shapes the structure of cortical receptive fields.

Date: 2022
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DOI: 10.1038/s41467-022-29999-7

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