Regio- and enantioselective remote hydroarylation using a ligand-relay strategy

Yuli He, Jiawei Ma, Huayue Song, Yao Zhang, Yong Liang (), You Wang () and Shaolin Zhu ()
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Yuli He: Nanjing University
Jiawei Ma: Nanjing University
Huayue Song: Nanjing University
Yao Zhang: Nanjing University
Yong Liang: Nanjing University
You Wang: Nanjing University
Shaolin Zhu: Nanjing University

Nature Communications, 2022, vol. 13, issue 1, 1-9

Abstract: Abstract The design of a single complicated chiral ligand to well-promote each step of an asymmetric cascade reaction is sometimes a formidable challenge in transition metal catalysis. In this work, a highly regio- and enantioselective Ni-catalysed migratory hydroarylation relay process has been achieved with the combination of two simple ligands, one which accomplishes chain-walking and the other causing asymmetric arylation. This formal asymmetric C(sp3)−H arylation provides direct access to a wide range of structurally diverse chiral 1,1-diarylalkanes, a structural unit found in a number of bioactive molecules. The value of this strategy was further demonstrated by the Ni-catalysed migratory asymmetric 1,3-arylboration.

Date: 2022
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DOI: 10.1038/s41467-022-30006-2

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