Kronos scRT: a uniform framework for single-cell replication timing analysis

Stefano Gnan, Joseph M. Josephides, Xia Wu, Manuela Spagnuolo, Dalila Saulebekova, Mylène Bohec, Marie Dumont, Laura G. Baudrin, Daniele Fachinetti, Sylvain Baulande and Chun-Long Chen ()
Additional contact information
Stefano Gnan: Institut Curie, PSL Research University, CNRS UMR3244, Dynamics of Genetic Information, Sorbonne Université
Joseph M. Josephides: Institut Curie, PSL Research University, CNRS UMR3244, Dynamics of Genetic Information, Sorbonne Université
Xia Wu: Institut Curie, PSL Research University, CNRS UMR3244, Dynamics of Genetic Information, Sorbonne Université
Manuela Spagnuolo: Institut Curie, PSL Research University, CNRS UMR3244, Dynamics of Genetic Information, Sorbonne Université
Dalila Saulebekova: Institut Curie, PSL Research University, CNRS UMR3244, Dynamics of Genetic Information, Sorbonne Université
Mylène Bohec: Institut Curie, Genomics of Excellence (ICGex) Platform, PSL Research University
Marie Dumont: Institut Curie, PSL Research University, CNRS UMR144, Cell Biology and Cancer
Laura G. Baudrin: Institut Curie, Genomics of Excellence (ICGex) Platform, PSL Research University
Daniele Fachinetti: Institut Curie, PSL Research University, CNRS UMR144, Cell Biology and Cancer
Sylvain Baulande: Institut Curie, Genomics of Excellence (ICGex) Platform, PSL Research University
Chun-Long Chen: Institut Curie, PSL Research University, CNRS UMR3244, Dynamics of Genetic Information, Sorbonne Université

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract Mammalian genomes are replicated in a cell type-specific order and in coordination with transcription and chromatin organization. Currently, single-cell replication studies require individual processing of sorted cells, yielding a limited number (

Date: 2022
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DOI: 10.1038/s41467-022-30043-x

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