Microwave assisted antibacterial action of Garcinia nanoparticles on Gram-negative bacteria

Yuqian Qiao, Yingde Xu, Xiangmei Liu (), Yufeng Zheng, Bo Li, Yong Han, Zhaoyang Li, Kelvin Wai Kwok Yeung, Yanqin Liang, Shengli Zhu, Zhenduo Cui and Shuilin Wu ()
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Yuqian Qiao: Tianjin University
Yingde Xu: Tianjin University
Xiangmei Liu: Hebei University of Technology
Yufeng Zheng: Peking University
Bo Li: Xi’an Jiaotong University
Yong Han: Xi’an Jiaotong University
Zhaoyang Li: Tianjin University
Kelvin Wai Kwok Yeung: The University of Hong Kong
Yanqin Liang: Tianjin University
Shengli Zhu: Tianjin University
Zhenduo Cui: Tianjin University
Shuilin Wu: Tianjin University

Nature Communications, 2022, vol. 13, issue 1, 1-13

Abstract: Abstract Owing to the existence of the outer membrane barrier, most antibacterial agents cannot penetrate Gram-negative bacteria and are ineffective. Here, we report a general method for narrow-spectrum antibacterial Garcinia nanoparticles that can only be effective to kill Gram-positive bacteria, to effectively eliminate Gram-negative bacteria by creating transient nanopores in bacterial outer membrane to induce drug entry under microwaves assistance. In vitro, under 15 min of microwaves irradiation, the antibacterial efficiency of Garcinia nanoparticles against Escherichia coli can be enhanced from 6.73% to 99.48%. In vivo, MV-assisted GNs can effectively cure mice with bacterial pneumonia. The combination of molecular dynamics simulation and experimental results reveal that the robust anti-E. coli effectiveness of Garcinia nanoparticles is attributed to the synergy of Garcinia nanoparticles and microwaves. This work presents a strategy for effectively treating both Gram-negative and Gram-positive bacteria co-infected pneumonia using herbal medicine nanoparticles with MV assistance as an exogenous antibacterial auxiliary.

Date: 2022
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DOI: 10.1038/s41467-022-30125-w

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