WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour

Shiu-Ling Chen, Bo-Ting Liu, Wang-Pao Lee, Sin-Bo Liao, Yao-Bang Deng, Chia-Lin Wu, Shuk-Man Ho, Bing-Xian Shen, Guan-Hock Khoo, Wei-Chiang Shiu, Chih-Hsuan Chang, Hui-Wen Shih, Jung-Kun Wen, Tsuo-Hung Lan, Chih-Chien Lin, Yu-Chen Tsai (), Huey-Fen Tzeng () and Tsai-Feng Fu ()
Additional contact information
Shiu-Ling Chen: National Chi Nan University
Bo-Ting Liu: National Chi Nan University
Wang-Pao Lee: College of Medicine, Chang Gung University
Sin-Bo Liao: National Chi Nan University
Yao-Bang Deng: National Chi Nan University
Chia-Lin Wu: College of Medicine, Chang Gung University
Shuk-Man Ho: National Chi Nan University
Bing-Xian Shen: National Chi Nan University
Guan-Hock Khoo: Tunghai University
Wei-Chiang Shiu: National Chi Nan University
Chih-Hsuan Chang: Tunghai University
Hui-Wen Shih: Tunghai University
Jung-Kun Wen: Institute of Biological Chemistry, Academia Sinica
Tsuo-Hung Lan: School of Medicine, National Yang Ming Chiao Tung University
Chih-Chien Lin: School of Medicine, National Yang Ming Chiao Tung University
Yu-Chen Tsai: Tunghai University
Huey-Fen Tzeng: National Chi Nan University
Tsai-Feng Fu: National Chi Nan University

Nature Communications, 2022, vol. 13, issue 1, 1-18

Abstract: Abstract The nervous and endocrine systems coordinate with each other to closely influence physiological and behavioural responses in animals. Here we show that WAKE (encoded by wide awake, also known as wake) modulates membrane levels of GABAA receptor Resistance to Dieldrin (Rdl), in insulin-producing cells of adult male Drosophila melanogaster. This results in changes to secretion of insulin-like peptides which is associated with changes in juvenile hormone biosynthesis in the corpus allatum, which in turn leads to a decrease in 20-hydroxyecdysone levels. A reduction in ecdysone signalling changes neural architecture and lowers the perception of the male-specific sex pheromone 11-cis-vaccenyl acetate by odorant receptor 67d olfactory neurons. These finding explain why WAKE-deficient in Drosophila elicits significant male-male courtship behaviour.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-022-30165-2 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30165-2

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-30165-2

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().