Vinyl copolymers with faster hydrolytic degradation than aliphatic polyesters and tunable upper critical solution temperatures

Amaury Bossion, Chen Zhu, Léa Guerassimoff, Julie Mougin and Julien Nicolas ()
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Amaury Bossion: Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay
Chen Zhu: Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay
Léa Guerassimoff: Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay
Julie Mougin: Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay
Julien Nicolas: Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract Vinyl polymers are the focus of intensive research due to their ease of synthesis and the possibility of making well-defined, functional materials. However, their non-degradability leads to environmental problems and limits their use in biomedical applications, allowing aliphatic polyesters to still be considered as the gold standards. Radical ring-opening polymerization of cyclic ketene acetals is considered the most promising approach to impart degradability to vinyl polymers. However, these materials still exhibit poor hydrolytic degradation and thus cannot yet compete with traditional polyesters. Here we show that a simple copolymerization system based on acrylamide and cyclic ketene acetals leads to well-defined and cytocompatible copolymers with faster hydrolytic degradation than that of polylactide and poly(lactide-co-glycolide). Moreover, by changing the nature of the cyclic ketene acetal, the copolymers can be either water-soluble or can exhibit tunable upper critical solution temperatures relevant for mild hyperthermia-triggered drug release. Amphiphilic diblock copolymers deriving from this system can also be formulated into degradable, thermosensitive nanoparticles by an all-water nanoprecipitation process.

Date: 2022
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DOI: 10.1038/s41467-022-30220-y

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