Quadrivalent mosaic HexaPro-bearing nanoparticle vaccine protects against infection of SARS-CoV-2 variants

Yin-Feng Kang, Cong Sun, Jing Sun, Chu Xie, Zhen Zhuang, Hui-Qin Xu, Zheng Liu, Yi-Hao Liu, Sui Peng, Run-Yu Yuan (), Jin-Cun Zhao () and Mu-Sheng Zeng ()
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Yin-Feng Kang: Sun Yat-sen University Cancer Center (SYSUCC), Sun Yat-sen University
Cong Sun: Sun Yat-sen University Cancer Center (SYSUCC), Sun Yat-sen University
Jing Sun: The First Affiliated Hospital of Guangzhou Medical University
Chu Xie: Sun Yat-sen University Cancer Center (SYSUCC), Sun Yat-sen University
Zhen Zhuang: The First Affiliated Hospital of Guangzhou Medical University
Hui-Qin Xu: Southern University of Science and Technology
Zheng Liu: Southern University of Science and Technology
Yi-Hao Liu: The First Affiliated Hospital of Sun Yat-sen University
Sui Peng: The First Affiliated Hospital of Sun Yat-sen University
Run-Yu Yuan: Guangdong Provincial Center for Disease Control and Prevention
Jin-Cun Zhao: The First Affiliated Hospital of Guangzhou Medical University
Mu-Sheng Zeng: Sun Yat-sen University Cancer Center (SYSUCC), Sun Yat-sen University

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract Emerging SARS-CoV-2 variants of concern (VOCs) harboring multiple mutations in the spike protein raise concerns on effectiveness of current vaccines that rely on the ancestral spike protein. Here, we design a quadrivalent mosaic nanoparticle vaccine displaying spike proteins from the SARS-CoV-2 prototype and 3 different VOCs. The mosaic nanoparticle elicits equivalent or superior neutralizing antibodies against variant strains in mice and non-human primates with only small reduction in neutralization titers against the ancestral strain. Notably, it provides protection against infection with prototype and B.1.351 strains in mice. These results provide a proof of principle for the development of multivalent vaccines against pandemic and potential pre-emergent SARS-CoV-2 variants.

Date: 2022
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DOI: 10.1038/s41467-022-30222-w

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