Systematic and quantitative view of the antiviral arsenal of prokaryotes

Florian Tesson, Alexandre Hervé, Ernest Mordret, Marie Touchon, Camille d’Humières, Jean Cury () and Aude Bernheim ()
Additional contact information
Florian Tesson: Université de Paris, IAME, UMR 1137, INSERM
Alexandre Hervé: Independent Researcher
Ernest Mordret: SEED, U1284, INSERM, Université de Paris
Marie Touchon: Institut Pasteur, Université de Paris, CNRS, UMR3525, Microbial Evolutionary Genomics
Camille d’Humières: Université de Paris, IAME, UMR 1137, INSERM
Jean Cury: SEED, U1284, INSERM, Université de Paris
Aude Bernheim: Université de Paris, IAME, UMR 1137, INSERM

Nature Communications, 2022, vol. 13, issue 1, 1-10

Abstract: Abstract Bacteria and archaea have developed multiple antiviral mechanisms, and genomic evidence indicates that several of these antiviral systems co-occur in the same strain. Here, we introduce DefenseFinder, a tool that automatically detects known antiviral systems in prokaryotic genomes. We use DefenseFinder to analyse 21000 fully sequenced prokaryotic genomes, and find that antiviral strategies vary drastically between phyla, species and strains. Variations in composition of antiviral systems correlate with genome size, viral threat, and lifestyle traits. DefenseFinder will facilitate large-scale genomic analysis of antiviral defense systems and the study of host-virus interactions in prokaryotes.

Date: 2022
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DOI: 10.1038/s41467-022-30269-9

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