Ni-catalyzed hydroarylation of alkynes with unactivated β-C(sp2)−H bonds

Shao-Long Qi, Yu-Peng Liu, Yi Li, Yu-Xin Luan and Mengchun Ye ()
Additional contact information
Shao-Long Qi: State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University
Yu-Peng Liu: State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University
Yi Li: State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University
Yu-Xin Luan: State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University
Mengchun Ye: State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University

Nature Communications, 2022, vol. 13, issue 1, 1-9

Abstract: Abstract Hydroarylation of alkynes with unactivated C(sp2)−H bonds via chelated C−H metalation mainly occurs at γ-position to the coordinating atom of directing groups via stable 5-membered metallacycles, while β-C(sp2)−H bond-involved hydroarylation has been a formidable challenge. Herein, we used a phosphine oxide-ligated Ni−Al bimetallic catalyst to enable β-C−H bond-involved hydroarylations of alkynes via a rare 7-membered nickelacycle.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-022-30367-8 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30367-8

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-30367-8

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().