Genomic diversity across the Rickettsia and ‘Candidatus Megaira’ genera and proposal of genus status for the Torix group

Helen R. Davison, Jack Pilgrim, Nicky Wybouw, Joseph Parker, Stacy Pirro, Simon Hunter-Barnett, Paul M. Campbell, Frances Blow, Alistair C. Darby, Gregory D. D. Hurst and Stefanos Siozios ()
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Helen R. Davison: University of Liverpool
Jack Pilgrim: University of Liverpool
Nicky Wybouw: Ghent University
Joseph Parker: California Institute of Technology
Stacy Pirro: Iridian Genomes
Simon Hunter-Barnett: University of Liverpool
Paul M. Campbell: University of Liverpool
Frances Blow: University of Liverpool
Alistair C. Darby: University of Liverpool
Gregory D. D. Hurst: University of Liverpool
Stefanos Siozios: University of Liverpool

Nature Communications, 2022, vol. 13, issue 1, 1-14

Abstract: Abstract Members of the bacterial genus Rickettsia were originally identified as causative agents of vector-borne diseases in mammals. However, many Rickettsia species are arthropod symbionts and close relatives of ‘Candidatus Megaira’, which are symbiotic associates of microeukaryotes. Here, we clarify the evolutionary relationships between these organisms by assembling 26 genomes of Rickettsia species from understudied groups, including the Torix group, and two genomes of ‘Ca. Megaira’ from various insects and microeukaryotes. Our analyses of the new genomes, in comparison with previously described ones, indicate that the accessory genome diversity and broad host range of Torix Rickettsia are comparable to those of all other Rickettsia combined. Therefore, the Torix clade may play unrecognized roles in invertebrate biology and physiology. We argue this clade should be given its own genus status, for which we propose the name ‘Candidatus Tisiphia’.

Date: 2022
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DOI: 10.1038/s41467-022-30385-6

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