Serotonin limits generation of chromaffin cells during adrenal organ development

Polina Kameneva, Victoria I. Melnikova, Maria Eleni Kastriti, Anastasia Kurtova, Emil Kryukov, Aliia Murtazina, Louis Faure, Irina Poverennaya, Artem V. Artemov, Tatiana S. Kalinina, Nikita V. Kudryashov, Michael Bader, Jan Skoda, Petr Chlapek, Lucie Curylova, Lukas Sourada, Jakub Neradil, Marketa Tesarova, Massimo Pasqualetti, Patricia Gaspar, Vasily D. Yakushov, Boris I. Sheftel, Tomas Zikmund, Jozef Kaiser, Kaj Fried, Natalia Alenina, Elena E. Voronezhskaya () and Igor Adameyko ()
Additional contact information
Polina Kameneva: Medical University Vienna
Victoria I. Melnikova: Russian Academy of Sciences
Maria Eleni Kastriti: Medical University Vienna
Anastasia Kurtova: Russian Academy of Sciences
Emil Kryukov: Medical University Vienna
Aliia Murtazina: Karolinska Institute
Louis Faure: Medical University Vienna
Irina Poverennaya: Medical University Vienna
Artem V. Artemov: Medical University Vienna
Tatiana S. Kalinina: Russian Academy of Sciences
Nikita V. Kudryashov: Russian Academy of Sciences
Michael Bader: Max-Delbrück Center for Molecular Medicine (MDC)
Jan Skoda: Masaryk University
Petr Chlapek: Masaryk University
Lucie Curylova: Masaryk University
Lukas Sourada: Masaryk University
Jakub Neradil: Masaryk University
Marketa Tesarova: Brno University of Technology
Massimo Pasqualetti: University of Pisa
Patricia Gaspar: INSERM, Paris Brain Institute
Vasily D. Yakushov: Russian Academy of Sciences
Boris I. Sheftel: Russian Academy of Sciences
Tomas Zikmund: Brno University of Technology
Jozef Kaiser: Brno University of Technology
Kaj Fried: Karolinska Institute
Natalia Alenina: Max-Delbrück Center for Molecular Medicine (MDC)
Elena E. Voronezhskaya: Russian Academy of Sciences
Igor Adameyko: Medical University Vienna

Nature Communications, 2022, vol. 13, issue 1, 1-21

Abstract: Abstract Adrenal glands are the major organs releasing catecholamines and regulating our stress response. The mechanisms balancing generation of adrenergic chromaffin cells and protecting against neuroblastoma tumors are still enigmatic. Here we revealed that serotonin (5HT) controls the numbers of chromaffin cells by acting upon their immediate progenitor “bridge” cells via 5-hydroxytryptamine receptor 3A (HTR3A), and the aggressive HTR3Ahigh human neuroblastoma cell lines reduce proliferation in response to HTR3A-specific agonists. In embryos (in vivo), the physiological increase of 5HT caused a prolongation of the cell cycle in “bridge” progenitors leading to a smaller chromaffin population and changing the balance of hormones and behavioral patterns in adulthood. These behavioral effects and smaller adrenals were mirrored in the progeny of pregnant female mice subjected to experimental stress, suggesting a maternal-fetal link that controls developmental adaptations. Finally, these results corresponded to a size-distribution of adrenals found in wild rodents with different coping strategies.

Date: 2022
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DOI: 10.1038/s41467-022-30438-w

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