Metabolic regulation by the intestinal metformin-AMPK axis

Song-Yang Zhang and Tony K. T. Lam ()
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Song-Yang Zhang: Toronto General Hospital Research Institute, UHN
Tony K. T. Lam: Toronto General Hospital Research Institute, UHN

Nature Communications, 2022, vol. 13, issue 1, 1-3

Abstract: AMP-activated protein kinase (AMPK) mediates the glucose-lowering effect of the antidiabetic agent metformin, but the sites of action remain unclear. In the March issue of Nature Communications, Zhang and colleagues reported that intestinal epithelium-specific AMPKα1 knockout mice fail to respond to metformin and exhibit disruption in metabolic homeostasis secondary to changes in the gut microbiome. This highlights a therapeutic potential of targeting intestinal AMPK for diabetes.

Date: 2022
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DOI: 10.1038/s41467-022-30477-3

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