Insights into methionine S-methylation in diverse organisms

Ming Peng, Chun-Yang Li (), Xiu-Lan Chen, Beth T. Williams, Kang Li, Ya-Nan Gao, Peng Wang, Ning Wang, Chao Gao, Shan Zhang, Marie C. Schoelmerich, Jillian F. Banfield, J. Benjamin Miller, Nick E. Brun, Jonathan D. Todd () and Yu-Zhong Zhang ()
Additional contact information
Ming Peng: Ocean University of China
Chun-Yang Li: Ocean University of China
Xiu-Lan Chen: Shandong University
Beth T. Williams: University of East Anglia
Kang Li: Pilot National Laboratory for Marine Science and Technology
Ya-Nan Gao: Ocean University of China
Peng Wang: Ocean University of China
Ning Wang: Shandong University
Chao Gao: Shandong University
Shan Zhang: Shandong University
Marie C. Schoelmerich: University of California, Berkeley
Jillian F. Banfield: University of California, Berkeley
J. Benjamin Miller: University of East Anglia
Nick E. Brun: University of East Anglia
Jonathan D. Todd: University of East Anglia
Yu-Zhong Zhang: Ocean University of China

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract Dimethylsulfoniopropionate (DMSP) is an important marine anti-stress compound, with key roles in global nutrient cycling, chemotaxis and, potentially, climate regulation. Recently, diverse marine Actinobacteria, α- and γ-proteobacteria were shown to initiate DMSP synthesis via the methionine (Met) S-methyltransferase enzyme (MmtN), generating S-methyl-Met (SMM). Here we characterize a roseobacterial MmtN, providing structural and mechanistic insights into this DMSP synthesis enzyme. We propose that MmtN uses the proximity and desolvation mechanism for Met S-methylation with two adjacent MmtN monomers comprising the Met binding site. We also identify diverse functional MmtN enzymes in potentially symbiotic archaeal Candidatus Woesearchaeota and Candidate Phyla Radiation (CPR) bacteria, and the animalcule Adineta steineri, not anticipated to produce SMM and/or DMSP. These diverse MmtN enzymes, alongside the larger plant MMT enzyme with an N-terminus homologous to MmtN, likely utilize the same proximity and desolvation mechanism. This study provides important insights into the catalytic mechanism of SMM and/or DMSP production, and proposes roles for these compounds in secondary metabolite production, and SMM cycling in diverse organisms and environments.

Date: 2022
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DOI: 10.1038/s41467-022-30491-5

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