Embryo-scale epithelial buckling forms a propagating furrow that initiates gastrulation

Julien Fierling, Alphy John, Barthélémy Delorme, Alexandre Torzynski, Guy B. Blanchard, Claire M. Lye, Anna Popkova, Grégoire Malandain, Bénédicte Sanson, Jocelyn Étienne (), Philippe Marmottant, Catherine Quilliet and Matteo Rauzi ()
Additional contact information
Julien Fierling: LIPhy
Alphy John: iBV
Barthélémy Delorme: iBV
Alexandre Torzynski: LIPhy
Guy B. Blanchard: University of Cambridge
Claire M. Lye: University of Cambridge
Anna Popkova: iBV
Grégoire Malandain: CNRS, I3S
Bénédicte Sanson: University of Cambridge
Jocelyn Étienne: LIPhy
Philippe Marmottant: LIPhy
Catherine Quilliet: LIPhy
Matteo Rauzi: iBV

Nature Communications, 2022, vol. 13, issue 1, 1-14

Abstract: Abstract Cell apical constriction driven by actomyosin contraction forces is a conserved mechanism during tissue folding in embryo development. While much is now understood of the molecular mechanism responsible for apical constriction and of the tissue-scale integration of the ensuing in-plane deformations, it is still not clear if apical actomyosin contraction forces are necessary or sufficient per se to drive tissue folding. To tackle this question, we use the Drosophila embryo model system that forms a furrow on the ventral side, initiating mesoderm internalization. Past computational models support the idea that cell apical contraction forces may not be sufficient and that active or passive cell apico-basal forces may be necessary to drive cell wedging leading to tissue furrowing. By using 3D computational modelling and in toto embryo image analysis and manipulation, we now challenge this idea and show that embryo-scale force balance at the tissue surface, rather than cell-autonomous shape changes, is necessary and sufficient to drive a buckling of the epithelial surface forming a furrow which propagates and initiates embryo gastrulation.

Date: 2022
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DOI: 10.1038/s41467-022-30493-3

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